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自由基水平变化导致 FLASH 效应：超高剂量率下的束结构参数对水中氧耗竭的影响。

Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water.

机构信息

Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Institute of Radiation Physics, Dresden, Germany.

出版信息

Radiother Oncol. 2022 Oct;175:193-196. doi: 10.1016/j.radonc.2022.08.024. Epub 2022 Aug 27.

DOI:10.1016/j.radonc.2022.08.024
PMID:36030933
Abstract

The influence of different average and bunch dose rates in electron beams on the FLASH effect was investigated. The present study measures O content in water at different beam pulse patterns and finds strong correlation with biological data, strengthening the hypothesis of radical-related mechanisms as a reason for the FLASH effect.

摘要

研究了电子束中不同平均剂量率和剂量率的影响对FLASH 效应的影响。本研究在不同的射束脉冲模式下测量了水中的 O 含量，并与生物学数据有很强的相关性，这加强了自由基相关机制是 FLASH 效应的原因的假设。

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