College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China.
College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China; Department of Nutrition and Health, China Agricultural University, Haidian, Beijing 100193, China.
Environ Pollut. 2022 Nov 1;312:120045. doi: 10.1016/j.envpol.2022.120045. Epub 2022 Aug 28.
Irregular or unnatural artificial light causes severe environmental stress on the survival and health of organisms, which is rapidly becoming a widespread new type of environmental pollution. A series of disruptive behaviors to body homeostasis brought about by light pollution, including metabolic abnormalities, are likely to be the result of circadian rhythm disturbances. Recently, the proposed role of light pollution in metabolic dysregulation has accelerated it into an emerging field. Hence, the regulatory role of light pollution in mammalian metabolic homeostasis is reviewed in this contribution. Light at night is the most widely affected type of light pollution, which disrupts metabolic homeostasis largely due to its disruption of daily food intake patterns, alterations of hormone levels such as melatonin and glucocorticoids, and changes in the rhythm of inflammatory factor production. Besides, light pollution impairs mammalian metabolic processes in an intensity-, photoperiod-, and wavelength-dependent manner, and is also affected by species, gender, and diets. Nevertheless, metabolic disorders triggered by light pollution are not irreversible to some extent. Potential interventions such as melatonin supplementation, recovery to the LD cycle, time-restricted feeding, voluntary exercise, wearing blue light-shied goggles, and bright morning light therapy open a bright avenue to prevent light pollution. This work will help strengthen the relationship between light information and metabolic homeostasis and provide new insights for the better prevention of metabolic disorders and light pollution.
不规则或不自然的人工光会对生物的生存和健康造成严重的环境压力，这种压力迅速成为一种广泛存在的新型环境污染。光污染会导致一系列破坏体内平衡的行为，包括代谢异常，这可能是由于昼夜节律紊乱所致。最近，光污染在代谢失调中的作用被提出，这使得它成为一个新兴领域。因此，本文综述了光污染对哺乳动物代谢稳态的调节作用。夜间光线是受影响最广泛的光污染类型，它主要通过扰乱日常的饮食模式、改变褪黑素和糖皮质激素等激素水平以及炎症因子产生的节律来破坏代谢稳态。此外，光污染以强度、光周期和波长依赖的方式损害哺乳动物的代谢过程，并且还受到物种、性别和饮食的影响。然而，在某种程度上，光污染引发的代谢紊乱并非不可逆转。一些潜在的干预措施，如褪黑素补充、恢复到明暗循环、限时喂养、自愿运动、佩戴防蓝光护目镜和明亮的晨光疗法，为预防光污染开辟了一条光明的道路。这项工作将有助于加强光信息与代谢稳态之间的关系，并为更好地预防代谢紊乱和光污染提供新的见解。
