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骆驼病毒性疾病:当前的诊断、治疗及预防策略

Camel viral diseases: Current diagnostic, therapeutic, and preventive strategies.

作者信息

Kandeel Mahmoud, Al-Mubarak Abdullah I A

机构信息

Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Hofuf, Saudi Arabia.

Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

出版信息

Front Vet Sci. 2022 Aug 11;9:915475. doi: 10.3389/fvets.2022.915475. eCollection 2022.

Abstract

Many pathogenic viruses infect camels, generally regarded as especially hardy livestock because of their ability to thrive in harsh and arid conditions. Transmission of these viruses has been facilitated by the commercialization of camel milk and meat and their byproducts, and vaccines are needed to prevent viruses from spreading. There is a paucity of information on the effectiveness of viral immunizations in camels, even though numerous studies have looked into the topic. More research is needed to create effective vaccines and treatments for camels. Because Camels are carriers of coronavirus, capable of producing a powerful immune response to recurrent coronavirus infections. As a result, camels may be a suitable model for viral vaccine trials since vaccines are simple to create and can prevent viral infection transfer from animals to humans. In this review, we present available data on the diagnostic, therapeutic, and preventative strategies for the following viral diseases in camels, most of which result in significant economic loss: camelpox, Rift Valley fever, peste des petits ruminants, bovine viral diarrhea, bluetongue, rotavirus, Middle East respiratory syndrome, and COVID-19. Although suitable vaccines have been developed for controlling viral infections and perhaps interrupting the transmission of the virus from the affected animals to blood-feeding vectors, there is a paucity of information on the effectiveness of viral immunizations in camels and more research is needed. Recent therapeutic trials that include specific antivirals or supportive care have helped manage viral infections.

摘要

许多致病性病毒感染骆驼,骆驼因其能够在恶劣和干旱条件下茁壮成长,通常被视为特别耐寒的牲畜。骆驼奶、肉及其副产品的商业化促进了这些病毒的传播,因此需要疫苗来防止病毒传播。尽管已有众多研究探讨了这一话题,但关于骆驼病毒免疫效果的信息却很少。需要进行更多研究来开发针对骆驼的有效疫苗和治疗方法。由于骆驼是冠状病毒的携带者,能够对复发性冠状病毒感染产生强大的免疫反应。因此,骆驼可能是病毒疫苗试验的合适模型,因为疫苗易于制备,并且可以防止病毒从动物传播给人类。在这篇综述中,我们提供了关于骆驼以下病毒性疾病的诊断、治疗和预防策略的现有数据,其中大多数疾病会导致重大经济损失:骆驼痘、裂谷热、小反刍兽疫、牛病毒性腹泻、蓝舌病、轮状病毒、中东呼吸综合征和新冠肺炎。尽管已经开发出了合适的疫苗来控制病毒感染,并可能中断病毒从受感染动物传播给吸血媒介,但关于骆驼病毒免疫效果的信息仍然很少,还需要更多的研究。最近包括特定抗病毒药物或支持性护理的治疗试验有助于控制病毒感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bc8/9403476/7a8e6b8ac1e5/fvets-09-915475-g0001.jpg

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