Sollie Martin, Jepsen Pernille, Sørensen Jens A
Research Unit for Plastic Surgery, Odense University Hospital, Odense, Denmark.
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Br J Pain. 2022 Aug;16(4):404-419. doi: 10.1177/20494637211073050. Epub 2022 Feb 21.
Herpes Zoster (HZ) is a common painful, debilitating condition caused by reactivation of the varicella-zoster virus. It is characterized by a painful skin eruption which is very complex to treat. Studies have reported that HZ negatively affects Quality of Life (QoL), but no large systematic review on this topic has been published to date. This systematic review aims to summarize the current data on patient-reported QoL amongst patients diagnosed with HZ.
We searched Medline, Embase, Cochrane Library, CINAHL, and PsycINFO. The primary outcome was the change in percent impairment of QoL compared to normative data. Secondary outcomes were meta-analyses comparing reported QoL to a control group or normative data.
We assessed a total of 536 studies for inclusion. Thirteen studies were included in the systematic review and five studies in the meta-analyses. The total number of patients was 5472.
This systematic review and meta-analysis found lower reported QoL amongst patients diagnosed with acute herpes zoster compared to normative values. Our data show that acute herpes zoster significantly reduces the quality of life of the patients affected.
带状疱疹（HZ）是由水痘-带状疱疹病毒再激活引起的一种常见的疼痛性、使人衰弱的疾病。其特征为疼痛性皮疹，治疗非常复杂。研究报告称，HZ对生活质量（QoL）有负面影响，但迄今为止尚未发表关于该主题的大型系统评价。本系统评价旨在总结目前关于带状疱疹确诊患者报告的生活质量的数据。
我们检索了医学期刊数据库（Medline）、荷兰医学文摘数据库（Embase）、考科蓝图书馆（Cochrane Library）、护理学与健康领域数据库（CINAHL）和心理学文摘数据库（PsycINFO）。主要结局是与标准数据相比，生活质量受损百分比的变化。次要结局是将报告的生活质量与对照组或标准数据进行比较的荟萃分析。
我们总共评估了536项研究以确定是否纳入。13项研究被纳入系统评价，5项研究被纳入荟萃分析。患者总数为5472人。
本系统评价和荟萃分析发现，与标准值相比，带状疱疹确诊患者报告的生活质量较低。我们的数据表明，急性带状疱疹显著降低了受影响患者的生活质量。
