使用自适应光学扫描激光检眼镜测量的黄斑中心凹视锥细胞地形图的评分者间一致性。
Intergrader agreement of foveal cone topography measured using adaptive optics scanning light ophthalmoscopy.
作者信息
Wynne Niamh, Cava Jenna A, Gaffney Mina, Heitkotter Heather, Scheidt Abigail, Reiniger Jenny L, Grieshop Jenna, Yang Kai, Harmening Wolf M, Cooper Robert F, Carroll Joseph
机构信息
Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI 53226, USA.
Joint Department of Biomedical Engineering, Medical College of Wisconsin and Marquette University, 1250 W Wisconsin Ave, Milwaukee, WI 53233, USA.
出版信息
Biomed Opt Express. 2022 Aug 1;13(8):4445-4454. doi: 10.1364/BOE.460821.
The foveal cone mosaic can be directly visualized using adaptive optics scanning light ophthalmoscopy (AOSLO). Previous studies in individuals with normal vision report wide variability in the topography of the foveal cone mosaic, especially the value of peak cone density (PCD). While these studies often involve a human grader, there have been no studies examining intergrader reproducibility of foveal cone mosaic metrics. Here we re-analyzed published AOSLO foveal cone images from 44 individuals to assess the relationship between the cone density centroid (CDC) location and the location of PCD. Across 5 graders with variable experience, we found a measurement error of 11.7% in PCD estimates and higher intergrader reproducibility of CDC location compared to PCD location (p < 0.0001). These estimates of measurement error can be used in future studies of the foveal cone mosaic, and our results support use of the CDC location as a more reproducible anchor for cross-modality analyses.
使用自适应光学扫描激光检眼镜（AOSLO）可以直接观察到中央凹视锥细胞镶嵌。先前对视力正常个体的研究报告称，中央凹视锥细胞镶嵌的地形图存在很大差异，尤其是视锥细胞峰值密度（PCD）的值。虽然这些研究通常涉及人工分级，但尚未有研究考察中央凹视锥细胞镶嵌指标在分级者之间的可重复性。在这里，我们重新分析了44名个体已发表的AOSLO中央凹视锥细胞图像，以评估视锥细胞密度质心（CDC）位置与PCD位置之间的关系。在5名经验各异的分级者中，我们发现PCD估计值的测量误差为11.7%，与PCD位置相比，CDC位置在分级者之间的可重复性更高（p < 0.0001）。这些测量误差估计值可用于未来对中央凹视锥细胞镶嵌的研究，我们的结果支持将CDC位置用作跨模态分析中更具可重复性的锚点。
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