Saud Zack, Richards Calvin A J, Williams Geraint, Stanton Richard J
Infection and Immunity, Medicine, Cardiff University, Heath Park, Cardiff CF11 9HH, UK.
Department of Materials Science and Engineering, Faculty of Science and Engineering, Bay Campus, Swansea University Crymlyn Burrows, Swansea SA1 8EN, UK.
Prog Org Coat. 2022 Nov;172:107135. doi: 10.1016/j.porgcoat.2022.107135. Epub 2022 Aug 22.
Viruses such as SARS-CoV-2 can remain viable on solid surfaces for up to one week, hence fomites are a potential route of exposure to infectious virus. Copper has well documented antiviral properties that could limit this problem, however practical deployment of copper surfaces has been limited due to the associated costs and the incompatibility of copper metal in specific environments and conditions. We therefore developed an organic coating containing an intelligent-release Cu pigment based on a cation exchange resin. Organic coatings containing a 50 % weight or higher loading of smart-release pigment were capable of completely inactivating (>6 log reduction in titre) SARS-CoV-2 within 4 h of incubation. Importantly these organic coatings demonstrated a significantly enhanced ability to inactivate SARS-CoV-2 compared to metallic copper and un-pigmented material. Furthermore, the presence of contaminating proteins inhibited the antiviral activity of metallic copper, but the intelligent-release Cu pigment was unaffected. The approach of using a very basic paint system, based on a polymer binder embedded with "smart release" pigment containing an anti-viral agent which is liberated by ion-exchange, holds significant promise as a cost effective and rapidly deployed coating to confer virus inactivating capability to high touch surfaces.
像严重急性呼吸综合征冠状病毒2（SARS-CoV-2）这样的病毒可以在固体表面存活长达一周，因此受污染的物体表面是接触传染性病毒的一个潜在途径。铜具有已被充分证明的抗病毒特性，这可能会限制这个问题，然而由于相关成本以及铜金属在特定环境和条件下的不兼容性，铜表面的实际应用受到了限制。因此，我们开发了一种基于阳离子交换树脂的含有智能释放铜颜料的有机涂层。含有50%重量或更高含量智能释放颜料的有机涂层能够在孵育4小时内完全灭活（滴度降低>6个对数）SARS-CoV-2。重要的是，与金属铜和无颜料材料相比，这些有机涂层灭活SARS-CoV-2的能力显著增强。此外，污染蛋白质的存在会抑制金属铜的抗病毒活性，但智能释放铜颜料不受影响。使用一种非常基础的涂料体系的方法，该体系基于嵌入含有通过离子交换释放抗病毒剂的“智能释放”颜料的聚合物粘合剂，作为一种具有成本效益且能快速部署的涂层，有望赋予高接触表面病毒灭活能力。
