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真菌细胞壁寡糖的合成及其触发植物免疫反应的能力。

Synthesis of Fungal Cell Wall Oligosaccharides and Their Ability to Trigger Plant Immune Responses.

作者信息

Chaube Manishkumar A, Trattnig Nino, Lee Du-Hwa, Belkhadir Youssef, Pfrengle Fabian

机构信息

Department of Biomolecular Systems Max Planck Institute of Colloids and Interfaces Am Mühlenberg 1 14476 Potsdam Germany.

Department of Chemistry University of Natural Resources and Life Sciences,Vienna Muthgasse 18 1190 Vienna Austria.

出版信息

European J Org Chem. 2022 Jul 21;2022(27):e202200313. doi: 10.1002/ejoc.202200313. Epub 2022 Jul 15.

DOI:10.1002/ejoc.202200313
PMID:36035813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9401017/
Abstract

Oligosaccharide fragments of fungal cell wall glycans are important molecular probes for studying both the biology of fungi and fungal infections of humans, animals, and plants. The fungal cell wall contains large amounts of various polysaccharides that are ligands for pattern recognition receptors (PRRs), eliciting an immune response upon recognition. Towards the establishment of a glycan array platform for the identification of new ligands of plant PRRs, tri-, penta-, and heptasaccharide fragments of different cell wall polysaccharides were prepared. Chito- and β-(1→6)-gluco-oligosaccharides were synthesized by automated glycan assembly (AGA), and α-(1→3)- and α-(1→4)-gluco-oligosaccharides were synthesized in solution using a recently reported highly α-selective glycosylation methodology. Incubation of plants with the synthesized oligosaccharides revealed i) length dependence for plant activation by chito-oligosaccharides and ii) β-1,6-glucan oligosaccharides as a new class of glycans capable of triggering plant activation.

摘要

真菌细胞壁聚糖的寡糖片段是研究真菌生物学以及人类、动物和植物真菌感染的重要分子探针。真菌细胞壁含有大量各种多糖，这些多糖是模式识别受体（PRR）的配体，识别后会引发免疫反应。为了建立一个用于鉴定植物PRR新配体的聚糖阵列平台，制备了不同细胞壁多糖的三糖、五糖和七糖片段。通过自动聚糖组装（AGA）合成了壳寡糖和β-（1→6）-葡寡糖，并使用最近报道的高度α-选择性糖基化方法在溶液中合成了α-（1→3）-和α-（1→4）-葡寡糖。用合成的寡糖处理植物后发现：i）壳寡糖对植物激活具有长度依赖性；ii）β-1,6-葡聚糖寡糖是一类能够触发植物激活的新聚糖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6431/9401017/80df54c06319/EJOC-2022-0-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6431/9401017/54468e393ade/EJOC-2022-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6431/9401017/100b4dd76452/EJOC-2022-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6431/9401017/68720bd2b9fe/EJOC-2022-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6431/9401017/80df54c06319/EJOC-2022-0-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6431/9401017/54468e393ade/EJOC-2022-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6431/9401017/100b4dd76452/EJOC-2022-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6431/9401017/68720bd2b9fe/EJOC-2022-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6431/9401017/80df54c06319/EJOC-2022-0-g004.jpg

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