Supramolecular Interfacial and Synthetic Chemistry Group, School of Physical Sciences, Ingram Building, University of Kent, CT2 7NH, Canterbury, UK.
School of Chemical and Physical Sciences, Lennard-Jones Building, Keele University, ST5 5BG, Staffordshire, UK.
Chemistry. 2022 Nov 25;28(66):e202202368. doi: 10.1002/chem.202202368. Epub 2022 Oct 1.
The ability to use bio-inspired building blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self-assemble into a reversibly porous, crystalline, supramolecular peptide framework (SPF). This framework is assembled from a short oligoproline, adopting the polyproline II conformation, driven by hydrogen-bonding and dispersion interactions. Thermal activation, guest-induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system. The principles of the self-assembly associated with this SPF will be used as a blueprint allowing for the further development of helical peptide linkers in the rational design of SPFs and metal-peptide frameworks.
利用仿生建筑模块来组装新型超分子框架处于激动人心的研究前沿。在此，我们首次展示了聚脯氨酸螺旋自组装成可还原的多孔、结晶的超分子肽骨架（SPF）。这个骨架是由一个短的寡聚脯氨酸，采用聚脯氨酸 II 构象，由氢键和色散相互作用驱动组装而成。该新体系已展示出热激活、客体诱导动态多孔性和对映体选择性客体包合的特性。与该 SPF 相关的自组装原理将作为蓝图，进一步开发螺旋肽连接子，以实现 SPF 和金属-肽骨架的合理设计。
