De Laurentiis Andrea, Correa Fernando, Fernandez Solari Javier
Universidad de Buenos Aires (UBA), Facultad de Odontología, Cátedra de Fisiología, Buenos Aires, Argentina.
Centro de Estudios Farmacológicos y Botánicos, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas (UBA/CONICET), Buenos Aires, Argentina.
J Endocr Soc. 2022 Aug 11;6(10):bvac120. doi: 10.1210/jendso/bvac120. eCollection 2022 Oct 1.
The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating not only their functions but also how they interplay with each other. Endogenous ligands, named endocannabinoids, are produced "on demand" to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well as to regulate the production of cytokines and other proinflammatory mediators. It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic-pituitary-adrenal axis but also affects other endocrine systems such as the hypothalamic-pituitary-gonadal axis and the release of oxytocin from the neurohypophysis. Here we explore which actors and molecular mechanisms are involved in these processes.
内源性大麻素系统在神经、内分泌和免疫系统的交叉作用中发挥着关键作用，不仅调节这些系统的功能，还调节它们之间的相互作用方式。内源性配体，即内源性大麻素，是“按需”产生的，以精细调节激素和神经递质的合成与分泌，以及调节细胞因子和其他促炎介质的产生。众所周知，免疫挑战，如接触革兰氏阴性细菌细胞壁的主要成分脂多糖，不仅会破坏下丘脑-垂体-肾上腺轴，还会影响其他内分泌系统，如下丘脑-垂体-性腺轴以及神经垂体释放催产素。在此，我们探讨哪些因素和分子机制参与了这些过程。
