个体规律体力活动差异的遗传途径。
Genetic Pathways Underlying Individual Differences in Regular Physical Activity.
机构信息
Department of Biological Psychology, VU University, and Amsterdam Public Health research institute, VU University Medical Center, Amsterdam, The Netherlands.
出版信息
Exerc Sport Sci Rev. 2023 Jan 1;51(1):2-18. doi: 10.1249/JES.0000000000000305. Epub 2022 Sep 1.
Twin and family studies show a strong contribution of genetic factors to physical activity (PA) assessed by either self-report or accelerometers. PA heritability is around 43% across the lifespan. Genome-wide association studies have implied biological pathways related to exercise ability and enjoyment. A polygenic score based on genetic variants influencing PA could help improve the success of intervention programs.
双胞胎和家系研究表明，遗传因素对通过自我报告或加速度计评估的身体活动（PA）有很大贡献。PA 的遗传力在整个生命周期中约为 43%。全基因组关联研究表明，与运动能力和运动享受相关的生物学途径。基于影响 PA 的遗传变异的多基因评分可能有助于提高干预计划的成功率。
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