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孕期和哺乳期给肥胖大鼠补充乳脂肪球膜可通过调节肠道微生物群促进子代神经发育。

Milk fat globule membrane supplementation to obese rats during pregnancy and lactation promotes neurodevelopment in offspring modulating gut microbiota.

作者信息

Yuan Qichen, Gong Han, Du Min, Li Tiange, Mao Xueying

机构信息

Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, Ministry of Education, China Agricultural University, Beijing, China.

Department of Animal Sciences, Washington State University, Pullman, WA, United States.

出版信息

Front Nutr. 2022 Aug 15;9:945052. doi: 10.3389/fnut.2022.945052. eCollection 2022.

DOI:10.3389/fnut.2022.945052
PMID:36046136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9421050/
Abstract

Pre-pregnancy obesity and high-fat diet (HFD) during pregnancy and lactation are associated with neurodevelopmental delay in offspring. This study aimed to investigate whether milk fat globule membrane (MFGM) supplementation in obese dams could promote neurodevelopment in offspring. Obese female rats induced by HFD were supplemented with MFGM during pregnancy and lactation. Maternal HFD exposure significantly delayed the maturation of neurological reflexes and inhibited neurogenesis in offspring, which were significantly recovered by maternal MFGM supplementation. Gut microbiota analysis revealed that MFGM supplementation modulated the diversity and composition of gut microbiota in offspring. The abundance of pro-inflammatory bacteria such as and were down-regulated, and the abundance of bacteria with anti-inflammatory and anti-obesity functions, such as and were up-regulated. Furthermore, MFGM alleviated neuroinflammation by decreasing the levels of lipopolysaccharides (LPS) and pro-inflammatory cytokines in the circulation and brain, as well as inhibiting the activation of microglia. Spearman's correlation analysis suggested that there existed a correlation between gut microbiota and inflammation-related indexes. In conclusion, maternal MFGM supplementation promotes neurodevelopment partly modulating gut microbiota in offspring.

摘要

孕前肥胖以及孕期和哺乳期的高脂饮食（HFD）与后代神经发育迟缓有关。本研究旨在调查肥胖母鼠补充乳脂肪球膜（MFGM）是否能促进后代的神经发育。通过高脂饮食诱导的肥胖雌性大鼠在怀孕和哺乳期补充乳脂肪球膜。母体暴露于高脂饮食会显著延迟后代神经反射的成熟并抑制神经发生，而母体补充乳脂肪球膜可使其显著恢复。肠道微生物群分析表明，补充乳脂肪球膜可调节后代肠道微生物群的多样性和组成。诸如 和 等促炎细菌的丰度下调，而具有抗炎和抗肥胖功能的细菌如 和 的丰度上调。此外，乳脂肪球膜通过降低循环和大脑中脂多糖（LPS）和促炎细胞因子的水平以及抑制小胶质细胞的激活来减轻神经炎症。Spearman相关性分析表明肠道微生物群与炎症相关指标之间存在相关性。总之，母体补充乳脂肪球膜部分通过调节后代肠道微生物群来促进神经发育。

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