Department of Sviluppo Sostenibile e la Transizione Ecologica, University of Piemonte Orientale, 13100 Vercelli, Italy.
Department of Scienze e Innovazione Tecnologica, University of Piemonte Orientale, 15121 Alessandria, Italy.
Nutrients. 2022 Oct 31;14(21):4574. doi: 10.3390/nu14214574.
Human milk is the ideal food for newborns until the age of six months. Human milk can be defined as a dynamic living tissue, containing immunological molecules, such as immunoglobulins, supra-molecular structures, such as the milk fat globule membrane (MFGM), and even entire cells, such as the milk microbiota. The milk composition changes throughout lactation to fulfill the infant's requirements and reflect the healthy/disease status of the lactating mother. Many bioactive milk components are either soluble or bound to the MFGM. In this work, we focus on the peculiar role of the MFGM components, from their structural organization in fat globules to their route into the gastrointestinal tract. Immunometabolic differences between human and bovine MFGM components are reported and the advantages of supplementing infant formula with the MFGM are highlighted.
人乳是新生儿在六个月大之前的理想食物。人乳可以被定义为一种动态的活体组织，其中包含免疫分子，如免疫球蛋白，超分子结构，如乳脂肪球膜（MFGM），甚至整个细胞，如乳微生物群。在哺乳期，人乳的成分会发生变化，以满足婴儿的需求，并反映哺乳期母亲的健康/疾病状况。许多生物活性的乳成分要么是可溶的，要么是与 MFGM 结合的。在这项工作中，我们专注于 MFGM 成分的特殊作用，从它们在脂肪球中的结构组织到它们进入胃肠道的途径。报告了人乳和牛乳 MFGM 成分的免疫代谢差异，并强调了在婴儿配方奶粉中添加 MFGM 的优势。
