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长链非编码RNA在瘢痕疙瘩中的新作用。

Emerging roles of long non-coding RNAs in keloids.

作者信息

Yu Xin, Zhu Xueqing, Xu Hongjun, Li Linfeng

机构信息

Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

出版信息

Front Cell Dev Biol. 2022 Aug 15;10:963524. doi: 10.3389/fcell.2022.963524. eCollection 2022.

DOI:10.3389/fcell.2022.963524
PMID:36046343
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9421354/
Abstract

Keloids are pathologic wound healing conditions caused by fibroblast hyperproliferation and excess collagen deposition following skin injury or irritation, which significantly impact patients by causing psychosocial and functional distress. Extracellular matrix (ECM) deposition and human fibroblast proliferation represents the main pathophysiology of keloid. Long non-coding RNAs (LncRNAs) play important roles in many biological and pathological processes, including development, differentiation and carcinogenesis. Recently, accumulating evidences have demonstrated that deregulated lncRNAs contribute to keloids formation. The present review summarizes the researches of deregulated lncRNAs in keloid. Exploring lncRNA-based methods hold promise as new effective therapies against keloid.

摘要

瘢痕疙瘩是由皮肤损伤或刺激后成纤维细胞过度增殖和胶原蛋白过度沉积引起的病理性伤口愈合状况，会导致心理社会和功能障碍，对患者产生重大影响。细胞外基质（ECM）沉积和人成纤维细胞增殖是瘢痕疙瘩的主要病理生理学特征。长链非编码RNA（LncRNAs）在许多生物学和病理过程中发挥重要作用，包括发育、分化和致癌作用。最近，越来越多的证据表明，失调的lncRNAs促成了瘢痕疙瘩的形成。本综述总结了失调的lncRNAs在瘢痕疙瘩中的研究。探索基于lncRNA的方法有望成为治疗瘢痕疙瘩的新有效疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6333/9421354/4c3ee2478056/fcell-10-963524-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6333/9421354/dd96bf6376cc/fcell-10-963524-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6333/9421354/f23469150a4d/fcell-10-963524-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6333/9421354/4c3ee2478056/fcell-10-963524-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6333/9421354/dd96bf6376cc/fcell-10-963524-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6333/9421354/f23469150a4d/fcell-10-963524-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6333/9421354/4c3ee2478056/fcell-10-963524-g003.jpg

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本文引用的文献

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CircSLC8A1 targets miR-181a-5p/HIF1AN pathway to inhibit the growth, migration and extracellular matrix deposition of human keloid fibroblasts.环状SLC8A1靶向miR-181a-5p/HIF1AN通路以抑制人瘢痕疙瘩成纤维细胞的生长、迁移及细胞外基质沉积。
Burns. 2023 May;49(3):622-632. doi: 10.1016/j.burns.2022.04.009. Epub 2022 Apr 22.
2
HOXA11-AS facilitates the proliferation, cell cycle process and migration of keloid fibroblasts through sponging miR-188-5p to regulate VEGFA.HOXA11-AS 通过海绵吸附 miR-188-5p 来调节 VEGFA，从而促进瘢痕疙瘩成纤维细胞的增殖、细胞周期进程和迁移。
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CircCOL5A1 inhibits proliferation, migration, invasion, and extracellular matrix production of keloid fibroblasts by regulating the miR-877-5p/EGR1 axis.
环状胶原蛋白COL5A1通过调控miR-877-5p/早期生长反应因子1轴抑制瘢痕疙瘩成纤维细胞的增殖、迁移、侵袭及细胞外基质生成。
Burns. 2023 Feb;49(1):137-148. doi: 10.1016/j.burns.2021.12.013. Epub 2022 Jan 5.
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Detection and analysis of long noncoding RNA expression profiles related to epithelial-mesenchymal transition in keloids.检测和分析与瘢痕疙瘩上皮-间充质转化相关的长非编码 RNA 表达谱。
Biomed Eng Online. 2022 Jan 11;21(1):2. doi: 10.1186/s12938-022-00976-x.
5
Long non-coding RNA H19 aggravates keloid progression by upregulating SMAD family member 5 expression via miR-196b-5p.长非编码 RNA H19 通过 miR-196b-5p 上调 SMAD 家族成员 5 的表达来加重瘢痕疙瘩的进展。
Bioengineered. 2022 Jan;13(1):1447-1458. doi: 10.1080/21655979.2021.2019868.
6
Lnc-H19 enhances anaerobic glycolysis of keloid fibroblasts by targeting the miR-214-5p/FGF2 axis.长链非编码RNA-H19通过靶向miR-214-5p/FGF2轴增强瘢痕疙瘩成纤维细胞的无氧糖酵解。
Burns. 2021 Aug 2. doi: 10.1016/j.burns.2021.07.015.
7
LncRNA HOXA11-AS aggravates the keloid formation by targeting miR-148b-3p/IGFBP5 axis.长链非编码 RNA HOXA11-AS 通过靶向 miR-148b-3p/IGFBP5 轴加剧瘢痕疙瘩的形成。
Biochem Biophys Res Commun. 2021 Dec 3;581:60-67. doi: 10.1016/j.bbrc.2021.09.074. Epub 2021 Oct 4.
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Histol Histopathol. 2021 Sep;36(9):995-1005. doi: 10.14670/HH-18-372. Epub 2021 Aug 23.
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Anal Biochem. 2021 Aug 15;627:114249. doi: 10.1016/j.ab.2021.114249. Epub 2021 May 25.
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LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway.长链非编码 RNA H19 通过靶向 miR-769-5p/EIF3A 通路促进瘢痕疙瘩形成。
Mol Cell Biochem. 2021 Mar;476(3):1477-1487. doi: 10.1007/s11010-020-04024-x. Epub 2021 Jan 3.