ChAdOx1 nCoV-19疫苗短期副作用的检测：在一个饱受战争蹂躏国家的横断面研究
Detection of Short-Term Side Effects of ChAdOx1 nCoV-19 Vaccine: A Cross-Sectional Study in a War-Torn Country.
作者信息
Alshakka Mohammed, Hatem Najmaddin A H, Badullah Wafa, Alsakaf Rabab, Rageh Ali, Yousef Seena Abdulla, Mohamed Ibrahim Mohamed Izham
机构信息
Section of Clinical Pharmacy, Faculty of Pharmacy, Aden University, Aden, Yemen.
Department of Pharmacy Practice, College of Clinical Pharmacy, Hodeidah University, Alhodeidah, Yemen.
出版信息
Pragmat Obs Res. 2022 Aug 25;13:85-91. doi: 10.2147/POR.S381836. eCollection 2022.
PURPOSE
The chAdOx1 nCoV-19 vaccine is the first COVID-19 vaccine available in Yemen. Hence, this local-based study was used to identify the type and frequency of short-term side effects following 48 hours of the first shot of the vaccine.
METHODS
A cross-section of vaccinated participants in Aden were surveyed by telephone. Descriptive statistics were used for statistical analysis.
RESULTS
A total of 500 participants were included through convenient sampling. 27% of them were health care providers. Nearly 70% of the respondent experienced side effects. The top three side effects reported were fever (n=276, 55.2%), myalgia (n=270, 54%) and fatigue (n=247, 49.4%). Generally, most participants stated that they experienced the side effects after the first 24 hours of vaccination.
CONCLUSION
Side effects that participants experienced were not different from the literature, indicating a safe profile for the vaccine. Further studies are needed to identify the side effects after the second and third dose of the vaccine. In addition, more studies are required to assess the efficacy of the existing vaccines against new variants.
目的
ChAdOx1 nCoV-19疫苗是也门可获得的首款新冠疫苗。因此，本基于当地的研究旨在确定接种该疫苗第一针48小时后短期副作用的类型和频率。
方法
通过电话对亚丁已接种疫苗的参与者进行横断面调查。采用描述性统计进行统计分析。
结果
通过便利抽样共纳入500名参与者。其中27%为医护人员。近70%的受访者出现了副作用。报告的前三大副作用为发热（n = 276，55.2%）、肌痛（n = 270，54%）和疲劳（n = 247，49.4%）。总体而言，大多数参与者表示他们在接种疫苗后的头24小时后出现了副作用。
结论
参与者经历的副作用与文献报道无异，表明该疫苗安全性良好。需要进一步研究来确定接种第二剂和第三剂疫苗后的副作用。此外，还需要更多研究来评估现有疫苗对新变种的有效性。
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