Department of Cardiology, Aerospace Center Hospital, Haidian District, Beijing, PR China.
PLoS One. 2023 Oct 13;18(10):e0292759. doi: 10.1371/journal.pone.0292759. eCollection 2023.
Copper (Cu) is a component that performs a crucial role in the normal function and development of the human body. Nonetheless, it is still largely unclear how Cu consumption in the diet relates to the risk for all-cause and cardiovascular disease (CVD) mortality.
Data from the National Health and Nutrition Examination Survey from 2001-2018 were used to conduct a prospective cohort study of individuals between the ages of 20 years and above. Regression coefficients and 95% confidence intervals for the link between dietary Cu consumption and all-cause and cardiovascular-related mortality were computed utilizing univariate and multivariate-adjusted Cox proportional hazards models.
A total of 197.9 million non-institutionalized American citizens were represented by the NHANES's 39,784 participants. The link between Cu in the diet and all-cause mortality was discovered to be non-linear in our restricted cubic spline regression models. When comparing the highest with the lowest quartile of Cu consumption in the diet, the weighted multivariate hazard ratios for all-cause mortality were 0.91 (0.83-0.99) for Q2, 0.88 (0.80-0.97) for Q3, and 0.86 (0.76-0.98) for Q4 (P for trend = 0.017). An identical trend was observed for cardiovascular mortality, but the association is not significant.
The most important discovery was that higher dietary Cu consumption was associated with a lower risk of all-cause mortality. This trend was also consistent with that of cardiovascular-related mortality, but the association is not significant.
铜（Cu）是人体正常功能和发育所必需的成分。然而，饮食中铜的摄入量与全因和心血管疾病（CVD）死亡率之间的关系仍在很大程度上不明确。
利用 2001-2018 年国家健康和营养调查（NHANES）的数据，对年龄在 20 岁及以上的个体进行了前瞻性队列研究。使用单变量和多变量调整的 Cox 比例风险模型，计算了饮食中铜摄入量与全因和心血管相关死亡率之间的关系的回归系数和 95%置信区间。
NHANES 的 39784 名参与者代表了 1.979 亿名非机构化的美国公民。我们的限制立方样条回归模型发现，饮食中铜与全因死亡率之间的关系是非线性的。当比较饮食中铜摄入量最高和最低四分位数时，全因死亡率的加权多变量风险比分别为 Q2 组为 0.91（0.83-0.99），Q3 组为 0.88（0.80-0.97），Q4 组为 0.86（0.76-0.98）（趋势 P 值=0.017）。心血管死亡率也观察到了相同的趋势，但关联不显著。
最重要的发现是，较高的饮食铜摄入量与较低的全因死亡率风险相关。这种趋势也与心血管相关死亡率一致，但关联不显著。
