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维生素 D 在神经精神疾病中的治疗和作用机制干预。

Therapeutic and mechanistic intervention of vitamin D in neuropsychiatric disorders.

机构信息

Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.

Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.

出版信息

Psychiatry Res. 2022 Nov;317:114782. doi: 10.1016/j.psychres.2022.114782. Epub 2022 Aug 14.

Abstract

Vitamin D deficiency is believed to affect between 35 and 55% of the world's population, making it a hidden pandemic. In addition to its role in bone and calcium homeostasis, vitamin D has also been linked in preclinical and clinical research to brain function. These outcomes have also been used for a variety of neuropsychiatric and neurodevelopmental problems. Nevertheless, these individuals are more prone to develop signs of cognitive decline. This review will emphasize the association between vitamin D and neuropsychiatric illnesses such as autism, schizophrenia, depression, and Attention Deficit Hyperactivity Disorder (ADHD). While numerous research show vitamin D's essential role in cognitive function in neuropsychiatric illnesses, it is too early to propose its effect on cognitive symptoms with certainty. It is necessary to conduct additional research into the associations between vitamin D deficiency and cognitive abnormalities, particularly those found in autism, schizophrenia, depression, and ADHD, to develop initiatives that address the pressing need for novel and effective preventative therapeutic strategies.

摘要

维生素 D 缺乏症被认为影响了全球 35%至 55%的人口,使其成为一种隐形的大流行病。除了在骨骼和钙稳态中的作用外,维生素 D 还在临床前和临床研究中与大脑功能有关。这些结果也被用于各种神经精神和神经发育问题。尽管如此,这些人更容易出现认知能力下降的迹象。这篇综述将重点强调维生素 D 与神经精神疾病之间的关联,如自闭症、精神分裂症、抑郁症和注意力缺陷多动障碍(ADHD)。虽然许多研究表明维生素 D 在神经精神疾病的认知功能中起着至关重要的作用,但现在就确定它对认知症状的影响还为时过早。有必要进一步研究维生素 D 缺乏与认知异常之间的关联,特别是在自闭症、精神分裂症、抑郁症和 ADHD 中发现的关联,以制定解决新型有效预防治疗策略迫切需求的计划。

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