Institute of Neuroscience and Medicine, Cognitive Neuroscience (INM3), Research Center Juelich, Jülich, Germany.
Faculty of Medicine and University Hospital Cologne, Department of Psychiatry, University of Cologne, Cologne, Germany.
Sci Rep. 2022 Sep 1;12(1):14853. doi: 10.1038/s41598-022-19309-y.
Differences in predictive processing are considered amongst the prime candidates for mechanisms underlying different symptoms of autism spectrum disorder (ASD). A particularly valuable paradigm to investigate these processes is temporal binding (TB) assessed through time estimation tasks. In this study, we report on two separate experiments using a TB task designed to assess the influence of top-down social information on action event related TB. Both experiments were performed with a group of individuals diagnosed with ASD and a matched group without ASD. The results replicate earlier findings on a pronounced social hyperbinding for social action-event sequences and extend them to persons with ASD. Hyperbinding however, is less pronounced in the group with ASD as compared to the group without ASD. We interpret our results as indicative of a reduced predictive processing during social interaction. This reduction most likely results from differences in the integration of top-down social information into action-event monitoring. We speculate that this corresponds to differences in mentalizing processes in ASD.
差异的预测处理被认为是潜在机制的主要候选者不同的自闭症谱系障碍（ASD）的症状。一个特别有价值的范式来研究这些过程是时间绑定（TB）评估通过时间估计任务。在这项研究中，我们报告了两个独立的实验使用一个 TB 任务旨在评估社会信息对动作事件相关 TB 的影响。两个实验都是由一组被诊断为 ASD 的个体和一组没有 ASD 的匹配个体完成的。结果复制了早期关于社会动作事件序列的明显社会超绑定的发现，并将其扩展到 ASD 患者。然而，与没有 ASD 的组相比，ASD 组的超绑定不那么明显。我们将我们的结果解释为社交互动过程中预测处理能力降低的迹象。这种减少很可能是由于自上而下的社会信息整合到动作事件监测中的差异造成的。我们推测这对应于 ASD 中心理化过程的差异。
