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光学相干断层扫描有望改变诊断解剖病理学大体评估过程。

Optical coherence tomography holds promise to transform the diagnostic anatomic pathology gross evaluation process.

机构信息

Columbia Univ., United States.

Boston Univ., United States.

出版信息

J Biomed Opt. 2022 Sep;27(9). doi: 10.1117/1.JBO.27.9.096003.

DOI:10.1117/1.JBO.27.9.096003
PMID:36050827
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9434002/
Abstract

SIGNIFICANCE

Real-time histology can close a variety of gaps in tissue diagnostics. Currently, gross pathology analysis of excised tissue is dependent upon visual inspection and palpation to identify regions of interest for histopathological processing. Such analysis is limited by the variable correlation between macroscopic and microscopic findings. The current standard of care is costly, burdensome, and inefficient.

AIM

We are the first to address this gap by introducing optical coherence tomography (OCT) to be integrated in real-time during the pathology grossing process.

APPROACH

This is achieved by our high-resolution, ultrahigh-speed, large field-of-view OCT device designed for this clinical application.

RESULTS

We demonstrate the feasibility of imaging tissue sections from multiple human organs (breast, prostate, lung, and pancreas) in a clinical gross pathology setting without interrupting standard workflows.

CONCLUSIONS

OCT-based real-time histology evaluation holds promise for addressing a gap that has been present for >100 years.

摘要

意义

实时组织学可以弥合组织诊断中的多种差距。目前，切除组织的大体病理分析依赖于视觉检查和触诊来识别用于组织病理学处理的感兴趣区域。这种分析受到宏观和微观发现之间的可变相关性的限制。当前的护理标准既昂贵又繁琐且效率低下。

目的

我们首次通过引入光学相干断层扫描 (OCT) 来解决这一差距，该技术在病理大体处理过程中实时集成。

方法

这是通过我们为该临床应用设计的高分辨率、超高速度、大视场 OCT 设备来实现的。

结果

我们展示了在不中断标准工作流程的情况下对来自多个人体器官（乳房、前列腺、肺和胰腺）的组织切片进行成像的可行性。

结论

基于 OCT 的实时组织学评估有望解决存在超过 100 年的差距。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/c4f202f65934/JBO-027-096003-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/5ddc59200509/JBO-027-096003-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/780ac8a954dd/JBO-027-096003-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/f501ef1d6703/JBO-027-096003-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/b72ee4e68cb3/JBO-027-096003-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/3e43523b89d0/JBO-027-096003-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/23dd2ef876a0/JBO-027-096003-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/1bacd44323f0/JBO-027-096003-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/9d5f96aab69c/JBO-027-096003-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/c4f202f65934/JBO-027-096003-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/5ddc59200509/JBO-027-096003-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/780ac8a954dd/JBO-027-096003-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/f501ef1d6703/JBO-027-096003-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/b72ee4e68cb3/JBO-027-096003-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/3e43523b89d0/JBO-027-096003-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/23dd2ef876a0/JBO-027-096003-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/1bacd44323f0/JBO-027-096003-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/9d5f96aab69c/JBO-027-096003-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e57/9434002/c4f202f65934/JBO-027-096003-g009.jpg

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