Kumar Alok, Ramamurthy H R, Tiwari Nikhil, Joshi Saajan, Kumar Gaurav, Kumar Vivek, Sharma Vipul
Department of Anaesthesia & Critical Care, Army Hospital (Research & Referral), Delhi Cantt, New Delhi 110010 India.
Department of Paediatrics, Army Hospital (Research & Referral), Delhi Cantt, New Delhi 110010 India.
Indian J Thorac Cardiovasc Surg. 2022 Sep;38(5):469-480. doi: 10.1007/s12055-022-01373-8. Epub 2022 May 26.
To assess the success of fast-tracking in infants and small children undergoing paediatric cardiac surgery under general anaesthesia with continuous thoracic epidural analgesia (TEA).
It is a retrospective study at a tertiary care hospital. A total of 461 children, aged 12 years or younger, were operated for congenital heart disease over a 2-year period from January 2018 to December 2019. After the exclusion of 71 patients, data from the remaining 390 patients were analysed.
The median time for extubation after intensive care unit admission was 2 h and 25 min (0-20 h). Extubation within 6 h was achieved in 215 patients (~ 55%). Patients in the early extubation group had significantly shorter hospital stay (4.1 ± 2.3 vs 6.9 ± 3.9 days, = 0.004) than patients in the ventilated group. Reintubation was required in 27 (6.9%) patients. Thirteen patients died postoperatively on ventilator. Patients with low nadir temperature intraoperatively and cardiopulmonary bypass time > 90 min significantly predicted failure in fast-tracking with an odds ratio (OR) = 1.27; CI: 1.18-1.38 and OR = 2.3; CI: 1.8-2.96 respectively. The Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Congenital Heart Surgery mortality score, younger age, Down syndrome and high vasopressor inotropic score did not adversely affect early extubation, contrary to contemporary concerns.
A multimodal approach for perioperative pain relief and sedation consisting of propofol and dexmedetomidine infusion along with TEA ensures early extubation in 59% of the cases undergoing paediatric cardiac surgery. Our data suggests that fast-tracking is feasible with safe and superior outcomes in a subset of appropriate patients undergoing paediatric cardiac surgery.
The online version contains supplementary material available at 10.1007/s12055-022-01373-8.
评估在全身麻醉联合持续胸椎硬膜外镇痛(TEA)下行小儿心脏手术的婴幼儿和儿童中实施快速康复的成效。
这是一项在三级护理医院开展的回顾性研究。在2018年1月至2019年12月的2年期间,共有461名12岁及以下的儿童接受了先天性心脏病手术。排除71名患者后,对其余390名患者的数据进行了分析。
重症监护病房入院后拔管的中位时间为2小时25分钟(0 - 20小时)。215名患者(约55%)在6小时内实现了拔管。早期拔管组患者的住院时间显著短于通气组患者(4.1±2.3天 vs 6.9±3.9天,P = 0.004)。27名(6.9%)患者需要再次插管。13名患者术后在呼吸机辅助下死亡。术中最低体温低和体外循环时间>90分钟的患者显著预示快速康复失败,优势比(OR)分别为1.27;CI:1.18 - 1.38和OR = 2.3;CI:1.8 - 2.96。与当代担忧相反,胸外科医师协会 - 欧洲心胸外科学会先天性心脏病手术死亡率评分、年龄较小、唐氏综合征和高血管活性药物肌力评分并未对早期拔管产生不利影响。
由丙泊酚和右美托咪定输注联合TEA组成的围手术期疼痛缓解和镇静多模式方法可确保59%的小儿心脏手术病例早期拔管。我们的数据表明,在一部分接受小儿心脏手术的合适患者中,快速康复是可行的,且具有安全和更好的结果。
在线版本包含可在10.1007/s12055 - 022 - 01373 - 8获取的补充材料。