West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Front Cell Infect Microbiol. 2022 Aug 16;12:980399. doi: 10.3389/fcimb.2022.980399. eCollection 2022.
Association of gastric atrophy or cancer with levels of serum pepsinogens, gastrin-17 and anti- IgG antibody have been extensively studied. However, the association of serum pepsinogen and gastrin-17 with infection has not been studied in a large population.
To investigate the impact of infection on serum levels of pepsinogens and gastrin-17.
A total of 354, 972 subjects who underwent health check-ups were included. Serum levels of pepsinogens and gastrin-17 were measured using the enzyme-linked immunosorbent assay infection was detected using C-urea breath test (UBT). Multivariable logistic regression analysis was used to investigate the association of serum pepsinogen and gastrin-17 with infection.
prevalence was 33.18% in this study. The mean levels of pepsinogens and gastrin-17 were higher, while the mean pepsinogen-I/II ratio were lower among -positive than -negative subjects. In -positive subjects, pepsinogen and gastrin-17 levels correlated positively, whereas the pepsinogen-I/II ratio correlated negatively with UBT values (e.g., the mean serum level of pepsinogen-I in subjects with UBT values in the range of 100-499dpm, 500-1499dpm, and ≥1500dpm was 94.77 ± 38.99, 102.77 ± 43.59, and 111.53 ± 47.47 ng/mL, respectively). Compared with -negative subjects, the adjusted odds ratio (aOR) of having pepsinogen-I ≤ 70 ng/mL in the three -positive but with different UBT value groups was 0.31 (<0.001), 0.16 (<0.001), and 0.08 (<0.001), respectively; while the aOR of having G-17>5.70 pmol/L was 4.56 (<0.001), 7.43 (<0.001), and 7.12 (<0.001). This suggested that -positive subjects with higher UBT values were less likely to have pepsinogen-I ≤70 ng/mL (a serum marker for gastric atrophy), but more likely to have gastrin-17 >5.70 pmol/L (a marker for peptic ulcer).
-positive subjects with higher UBT values are unlikely to have gastric atrophy, but may have greater risk of severe gastritis or peptic ulcers. Our study suggests that -positive patients with high UBT values may benefit the most from eradication.
胃萎缩或胃癌与血清胃蛋白酶原、胃泌素-17 和抗 IgG 抗体水平的关系已被广泛研究。然而，在大规模人群中，尚未研究血清胃蛋白酶原和胃泌素-17 与感染的关系。
探讨感染对血清胃蛋白酶原和胃泌素-17 水平的影响。
共纳入 354972 名接受健康检查的受试者。采用酶联免疫吸附试验检测血清胃蛋白酶原和胃泌素-17 水平，采用 C-尿素呼气试验（UBT）检测感染。采用多变量 logistic 回归分析探讨血清胃蛋白酶原和胃泌素-17 与感染的关系。
本研究中感染的患病率为 33.18%。与感染阴性者相比，感染阳性者的胃蛋白酶原和胃泌素-17 水平较高，而胃蛋白酶原 I/II 比值较低。在感染阳性者中，胃蛋白酶原和胃泌素-17 水平呈正相关，而胃蛋白酶原 I/II 比值与 UBT 值呈负相关（例如，UBT 值在 100-499dpm、500-1499dpm 和≥1500dpm 范围内的受试者的血清胃蛋白酶原 I 平均水平分别为 94.77±38.99、102.77±43.59 和 111.53±47.47ng/mL）。与感染阴性者相比，在三个 UBT 值不同的感染阳性但但 pepsinogen-I≤70ng/mL 的亚组中，调整后的优势比（aOR）分别为 0.31（<0.001）、0.16（<0.001）和 0.08（<0.001）；而 G-17>5.70pmol/L 的 aOR 分别为 4.56（<0.001）、7.43（<0.001）和 7.12（<0.001）。这表明，UBT 值较高的感染阳性者不太可能出现胃蛋白酶原 I≤70ng/mL（胃萎缩的血清标志物），但更可能出现胃泌素-17>5.70pmol/L（消化性溃疡的标志物）。
UBT 值较高的感染阳性者不太可能出现胃萎缩，但可能患有更严重的胃炎或消化性溃疡。我们的研究表明，UBT 值较高的感染阳性患者可能最受益于根除。
