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年龄增长不影响全髋关节置换术后髋关节特定功能结局或健康相关生活质量:一项为期五年的前瞻性队列研究。

Increasing age does not influence hip-specific functional outcome or health-related quality of life following total hip arthroplasty : a five-year prospective cohort study.

作者信息

Clement Nick D, Smith Karen M, Baron Y J, McColm Heidi, Deehan David J, Holland James

机构信息

Department of Orthopaedics, The Freeman Hospital, Newcastle, UK.

Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.

出版信息

Bone Jt Open. 2022 Sep;3(9):692-700. doi: 10.1302/2633-1462.39.BJO-2022-0085.R1.

Abstract

AIMS

The primary aim of our study was to assess the influence of age on hip-specific outcome following total hip arthroplasty (THA). Secondary aims were to assess health-related quality of life (HRQoL) and level of activity according to age.

METHODS

A prospective cohort study was conducted. All patients were fitted with an Exeter stem with a 32 mm head on highly cross-linked polyethylene (X3RimFit) cemented acetabulum. Patients were recruited into three age groups: < 65 years, 65 to 74 years, and ≥ 75 years, and assessed preoperatively and at three, 12, 24, and 60 months postoperatively. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Harris Hip Score (HHS), and Hip disability and Osteoarthritis Outcome Score (HOOS), were used to assess hip-specific outcome. EuroQol five-dimension five-level questionnaire (EQ-5D-5L) and 36-Item Short Form Survey (SF-36) scores were used to assess HRQoL. The Lower Extremity Activity Scale (LEAS) and Timed Up and Go (TUG) were used to assess level of activity.

RESULTS

There were no significant (p > 0.05) differences in the WOMAC scores, HSS, HOOS, or EQ-5D-5L at any postoperative timepoint between the age groups. Patients aged ≥ 75 years had significantly lower physical function (p ≤ 0.010) and physical role (p ≤ 0.047) SF-36 scores at 12, 24, and 60 months, but were equal to that expect of an age-matched population. No differences according to age were observed for the other six domains of the SF-36 (p > 0.060). The ≥ 75 years group had a lower LEAS (p < 0.001) and longer TUG test times (p ≤ 0.032) compared to the < 65 years group, but older age groups had significant (p < 0.001) improvement relative to their preoperative baseline measures.

CONCLUSION

Age did not influence postoperative hip-specific outcome or HRQoL (according to the EQ-5D) following THA. Despite a significant improvement, older patients had lower postoperative activity levels compared to younger patients, but this may be reflective of the overall physical effect of ageing.Cite this article:  2022;3(9):692-700.

摘要

目的

本研究的主要目的是评估年龄对全髋关节置换术(THA)后髋关节特定结局的影响。次要目的是根据年龄评估健康相关生活质量(HRQoL)和活动水平。

方法

进行了一项前瞻性队列研究。所有患者均使用 Exeter 柄和 32 毫米股骨头,安装在高度交联聚乙烯(X3RimFit)骨水泥髋臼上。患者被分为三个年龄组:<65 岁、65 至 74 岁和≥75 岁,并在术前以及术后 3 个月、12 个月、24 个月和 60 个月进行评估。使用西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、Harris 髋关节评分(HHS)以及髋关节残疾和骨关节炎结局评分(HOOS)来评估髋关节特定结局。使用欧洲五维健康量表(EQ-5D-5L)和 36 项简短健康调查(SF-36)评分来评估 HRQoL。使用下肢活动量表(LEAS)和计时起立行走测试(TUG)来评估活动水平。

结果

各年龄组在任何术后时间点的 WOMAC 评分、HSS、HOOS 或 EQ-5D-5L 均无显著差异(p>0.05)。≥75 岁的患者在术后 12 个月、24 个月和 60 个月时,SF-36 的身体功能(p≤0.010)和身体角色(p≤0.047)评分显著较低,但与年龄匹配人群的预期评分相当。SF-36 的其他六个领域在各年龄组间未观察到差异(p>0.060)。与<65 岁组相比,≥75 岁组的 LEAS 较低(p<0.001),TUG 测试时间较长(p≤0.032),但老年组相对于术前基线测量有显著改善(p<0.001)。

结论

年龄不影响 THA 术后的髋关节特定结局或 HRQoL(根据 EQ-5D)。尽管有显著改善,但老年患者术后的活动水平低于年轻患者,这可能反映了衰老对整体身体的影响。引用本文:2022;3(9):692-700。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9009/9533248/e7e02de85801/BJO-3-692-g0001.jpg

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