College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Huajin Orthopaedic Hospital, Taiyuan, 030024, China.
Med Biol Eng Comput. 2022 Oct;60(10):3019-3028. doi: 10.1007/s11517-022-02653-6. Epub 2022 Sep 2.
The complex structure and composition of articular cartilage make its performance show depth-dependent characteristics, but its related parameters are not complete at present. In this study, porcine articular cartilage was divided into three zones along the thickness direction, and the cartilage tissue in each zone was tested for electrical impedance, compression relaxation, and permeability to obtain their mechanical and electrical impedance parameters. The results showed that there were significant differences in mechanical and electrical properties of cartilage tissue in different zones in which resistivity, elastic modulus, relaxation time, and final relaxation rate increased gradually from superficial zone to deep zone along the direction of cartilage thickness while the permeability decreased gradually. Bioimpedance analysis can capture the phenomenon of very slight histological changes, which is expected to provide information for predicting cartilage degeneration, but the electrical impedance parameters of cartilage are still very lacking. These data are expected to provide reference for the treatment of clinical osteoarthritis and the research of cartilage repair materials.
关节软骨的复杂结构和组成使其性能呈现出深度依赖性特征，但目前其相关参数并不完整。本研究沿厚度方向将猪关节软骨分为三个区带，对每个区带的软骨组织进行了电阻抗、压缩松弛和渗透性测试，以获得其力学和电阻抗参数。结果表明，不同区带的软骨组织在力学和电学性能上存在显著差异，其中电阻率、弹性模量、松弛时间和最终松弛率沿软骨厚度方向从浅层到深层逐渐增加，而渗透性则逐渐降低。生物电阻抗分析可以捕捉到非常细微的组织学变化现象，有望为预测软骨退变提供信息，但软骨的电阻抗参数仍然非常缺乏。这些数据有望为临床骨关节炎的治疗和软骨修复材料的研究提供参考。
