对阿尔茨海默病患者指甲中微量元素水平的纵向变化进行研究。
A search for longitudinal variations in trace element levels in nails of Alzheimer's disease patients.
作者信息
Vance D E, Ehmann W D, Markesbery W R
机构信息
Department of Chemistry, University of Kentucky, Lexington 40506.
出版信息
Biol Trace Elem Res. 1990 Jul-Dec;26-27:461-70. doi: 10.1007/BF02992701.
PMID:1704751
Abstract
Levels of Br, Hg, K, and Zn were determined by INAA in the nails of Alzheimer's disease (AD) patients at 6-mo intervals for up to 3 yr. These elements have been shown to be imbalanced in AD nail. Bromine showed no trends. Mercury tended to decrease in nail with increasing age of patient, and with the duration and severity of the dementia. Potassium and Zn tended to increase with these same factors. Hence, progressive changes in trace-element levels do occur in AD nail, although imbalances are detected even in the earliest sampled stages of the disease.
摘要
采用仪器中子活化分析（INAA）方法，对阿尔茨海默病（AD）患者的指甲进行检测，每隔6个月检测一次，最长检测3年，以测定溴、汞、钾和锌的含量。研究表明，这些元素在AD患者指甲中的含量失衡。溴含量无明显变化趋势。随着患者年龄的增加、痴呆病程的延长和病情的加重，指甲中的汞含量呈下降趋势。钾和锌含量则随上述因素呈上升趋势。因此，AD患者指甲中的微量元素水平确实会发生渐进性变化，不过即使在疾病最早采样阶段也能检测到元素失衡情况。
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