Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University Health Service, Seoul, Republic of Korea.
Department of Oral and Maxillofacial Surgery, University of Illinois Chicago, Illinois, USA.
Sci Rep. 2022 Sep 2;12(1):14953. doi: 10.1038/s41598-022-16921-w.
The purpose of this study is to evaluate the degree of spontaneous bone healing after cyst enucleation as well as its contributing factors. Pre- and post-operative computed tomography (CT) scans of consecutive patients who had undergone jaw cyst enucleation were retrospectively analyzed. The outcome variable was healing ratio, which was calculated using the volume of the cyst before surgery and the volume of the defect in the bone after surgery. Predictor variables including duration of observation, pre-operative cyst size, age, gender, and involved jaw were analyzed to determine their influence. Forty-four subjects (30 Male and 14 Female, average 40.7 ± 15.7 years) were included in this study. Healing ratio was significantly lower during the first year (33.5 ± 32.8%) compared to the second (74.5 ± 24.2%) and subsequent years (74.2 ± 17.8%). In 35 patients who had follow-ups of over 1 year, the healing ratio was not affected by the pre-operative cyst size and upper/lower jaw except gender (p = 0.037, female > male) and age (p = 0.021, younger than 30 years > 30 years and older). The residual defect was significant larger in cysts 3 cc or larger (1.64 ± 1.54 cc) compared to smaller cysts (0.43 ± 0.42 cc, p = 0.006). The residual defect volume of large cysts was similar to those of the pre-operative volume of small cysts (1.47 ± 0.72 cc). In conclusion, spontaneous bone healing ratio of post-enucleation defects was about 73.5% after 12 months. Large cysts (> 3 cc) had larger defect, comparable to the volume of small cysts, but with altered contour. Additional treatment such as a bone graft may be considered especially in large cysts.
本研究旨在评估颌骨囊肿切除术后自发性骨愈合的程度及其影响因素。回顾性分析了连续接受颌骨囊肿切除术的患者的术前和术后计算机断层扫描（CT）扫描。结果变量为愈合率，通过手术前囊肿的体积和手术后骨缺损的体积计算得出。分析了包括观察时间、术前囊肿大小、年龄、性别和受累颌骨在内的预测变量，以确定其影响。本研究纳入了 44 名受试者（30 名男性和 14 名女性，平均年龄 40.7 ± 15.7 岁）。与第二年（74.5 ± 24.2%）和随后的年份（74.2 ± 17.8%）相比，第一年的愈合率明显较低（33.5 ± 32.8%）。在 35 名随访时间超过 1 年的患者中，除性别（p=0.037，女性>男性）和年龄（p=0.021，小于 30 岁>30 岁及以上）外，术前囊肿大小和上下颌对愈合率没有影响。3cc 或更大的囊肿（1.64 ± 1.54cc）的残余缺损明显大于较小的囊肿（0.43 ± 0.42cc，p=0.006）。大囊肿的残余缺损体积与小囊肿的术前体积相似（1.47 ± 0.72cc）。总之，术后 12 个月，囊肿切除术后骨缺损的自发性骨愈合率约为 73.5%。大囊肿（>3cc）的缺损较大，与小囊肿的体积相当，但形态发生改变。可能需要额外的治疗，如植骨。
