Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Life Sci. 2022 Nov 1;308:120922. doi: 10.1016/j.lfs.2022.120922. Epub 2022 Sep 1.
Renal cell carcinoma (RCC) is one of the most common kidney cancers, responsible for nearly 90 % of all renal malignancies. Despite the availability of many treatment strategies, RCC still remains to be an incurable disease due to its resistivity towards conventional therapies. Nanotechnology is an emerging field of science that offers newer possibilities in therapeutics including cancer medicine, specifically by targeted delivery of anticancer drugs. Several phytochemicals are known for their anti-cancer properties and have been regarded as chemopreventive agents. However, the hydrophobic nature of many phytochemicals decreases its bioavailability and distribution, thus showing limited therapeutic effect. Application of nanotechnology to enhance chemoprevention is an effective strategy to increase the bioavailability of phytochemicals and thereby its therapeutic efficacy. The present review focuses on the utility of nanotechnology in RCC treatment and chemopreventive agents of RCC. We have also visualized the future prospects of nanomolecules in the prevention and cure of RCC.
肾细胞癌（RCC）是最常见的肾癌之一，占所有肾脏恶性肿瘤的近 90%。尽管有许多治疗策略，但由于其对常规治疗的耐药性，RCC 仍然是一种无法治愈的疾病。纳米技术是一门新兴的科学领域，为治疗学提供了新的可能性，包括癌症医学，特别是通过靶向递送达癌药物。许多植物化学物质因其抗癌特性而被认为是化学预防剂。然而，许多植物化学物质的疏水性降低了其生物利用度和分布，因此表现出有限的治疗效果。应用纳米技术增强化学预防是增加植物化学物质生物利用度从而提高其治疗效果的有效策略。本综述重点介绍了纳米技术在 RCC 治疗和 RCC 化学预防剂中的应用。我们还展望了纳米分子在预防和治疗 RCC 中的未来前景。
