High Council for Public Health, Ministry of Solidarity and Health, Paris, France.
High Council for Public Health, Ministry of Solidarity and Health, Paris, France.
Clin Microbiol Infect. 2022 Dec;28(12):1572-1577. doi: 10.1016/j.cmi.2022.08.018. Epub 2022 Sep 2.
Since April 2022, a large number of monkeypox (MPX) cases have emerged across the globe in regions that are known to be totally free of zoonotic reservoir. The High Council for Public Health is a national institute commissioned to provide guidelines to the French Ministry of Health. The objective of these guidelines and recommendations is to inform the public, people at risk of severe MPX infection, infected patients and their families and contacts and healthcare workers in charge of infected patients.
A review of the literature from the MEDLINE database was carried out using the single keyword 'monkeypox', including recent and older articles from January 2000 to June 2022. There was no filter for the type of study, except English language. The titles and summaries of all the articles were read by the experts to select articles of interest. The High Council for Public Health brought together specialists with expertise in the field to analyse the scientific literature and international recommendations. Recommendations were classified with clinical practice methodology using four levels (strong recommendation, recommendation, optional recommendation and no recommendation) without grading the level of evidence. To develop and methodologically validate the recommendations, the Appraisal of Guidelines for Research and Evaluation Instrument (AGREE-II)chart was partially used. QUESTIONS ADDRESSED BY THE GUIDELINES AND RECOMMENDATIONS: (a) What are the therapeutic management measures for hospitalized patients with severe forms of MPX infection, and what are the preventive measures to protect healthcare professionals? (b) What are the isolation and prevention measures in the community for patients with mild or moderate severity MPX infection? (c) what are the preventive measures for contacts of an MPX-infected person? (d) Who should be vaccinated? (e) What are the specific prevention measures for children and schools?
自 2022 年 4 月以来，在已知没有动物传染病储存库的地区，全球范围内出现了大量猴痘（MPX）病例。公共卫生高级理事会是一个受委托向法国卫生部提供指导方针的国家机构。这些指南和建议的目的是告知公众、有严重 MPX 感染风险的人、感染患者及其家人和接触者以及负责感染患者的医护人员。
使用 MEDLINE 数据库中的单个关键字“monkeypox”对文献进行了回顾，包括 2000 年 1 月至 2022 年 6 月的近期和旧文章。除了英语外，没有对研究类型进行筛选。所有文章的标题和摘要均由专家阅读，以选择有兴趣的文章。公共卫生高级理事会召集了在该领域具有专业知识的专家，以分析科学文献和国际建议。建议使用临床实践方法进行分类，分为四级（强烈推荐、推荐、可选推荐和不推荐），而不分级证据水平。为了制定和验证建议的方法学，部分使用了评估指南研究和评估工具（AGREE-II）图表。指南和建议回答的问题：（a）患有严重 MPX 感染的住院患者的治疗管理措施是什么，保护医护人员的预防措施是什么？（b）患有轻度或中度 MPX 感染的患者在社区中的隔离和预防措施是什么？（c）MPX 感染者的接触者应采取哪些预防措施？（d）谁应该接种疫苗？（e）儿童和学校的具体预防措施是什么？
