Kazakov O V, Kabakov A V, Poveshchenko A F, Cherkas V N
Research Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2024 Dec;178(2):233-236. doi: 10.1007/s10517-025-06313-1. Epub 2025 Jan 7.
We studied the expression levels of microRNAs (miR-21, miR-27a, miR-221, and miR-429) in the thymus of female Wistar rats after surgical treatment of breast cancer (BC) and after photodynamic therapy for BC followed by tumor resection. In the group without treatment, the levels of pro-oncogenic miR-21, miR-27a, and miR-221 in the thymus were reduced in comparison with those in the group of intact control. After surgical treatment of BC, the levels of miR-21 and miR-27a in the thymus increased in comparison with those in BC without treatment. Surgical removal of the tumor followed by photodynamic therapy led to an even greater increase in the levels of miR-21 and miR-27a in the thymus in comparison with those in the group of surgical treatment alone. Expression of the tumor-suppressive miR-429 in the thymus significantly exceeds the levels in the BC without treatment and BC+surgery groups.
我们研究了雌性Wistar大鼠在乳腺癌（BC）手术治疗后以及BC光动力治疗后再进行肿瘤切除时，胸腺中微小RNA（miR-21、miR-27a、miR-221和miR-429）的表达水平。在未治疗组中，胸腺中促癌性miR-21、miR-27a和miR-221的水平与完整对照组相比有所降低。BC手术治疗后，胸腺中miR-21和miR-27a的水平与未治疗的BC组相比有所升高。手术切除肿瘤后再进行光动力治疗，与单纯手术治疗组相比，胸腺中miR-21和miR-27a的水平进一步显著升高。胸腺中肿瘤抑制性miR-429的表达明显超过未治疗的BC组和BC+手术组中的水平。
