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霉酚酸酯治疗的老年患者中,颅内出血与单核细胞增生李斯特菌菌血症相关。

Intracranial Hemorrhage Associated With Listeria monocytogenes Bacteremia in an Elderly Patient on Mycophenolate Mofetil.

作者信息

Alammora Abdelkarim, Elamin Ahmed

机构信息

Internal Medicine Department, Hamad Medical Corporation, Doha, QAT.

出版信息

Cureus. 2022 Aug 1;14(8):e27562. doi: 10.7759/cureus.27562. eCollection 2022 Aug.

Abstract

is an important foodborne bacterial pathogen in immunosuppressed patients, pregnant women, and individuals at the extremes of age, including neonates and older adults. Invasion of the central nervous system (CNS) and bacteremia are the principal clinical manifestations of infection in these hosts. In contrast, normal hosts who ingest high numbers of  may develop self-limited febrile gastroenteritis. Hydrocephalus and intracranial hemorrhage (ICH) are very rare and severe complications of infection. ICH associated with  has been reported even less frequently than hydrocephalus, with most cases occurring in the pediatric population. In this paper, we present a case of bacteremia in a 71-year-old male, complicated by intracranial hemorrhage. He presented at first with nonspecific symptoms of generalized weakness and fatigability and later developed drowsiness, disorientation, and fever, which prompted further investigations that revealed the presence of ICH and  bacteremia.

摘要

是免疫抑制患者、孕妇以及极端年龄人群(包括新生儿和老年人)中一种重要的食源性病原体。侵入中枢神经系统(CNS)和菌血症是这些宿主感染的主要临床表现。相比之下,摄入大量该病原体的正常宿主可能会发生自限性发热性胃肠炎。脑积水和颅内出血(ICH)是该病原体感染非常罕见且严重的并发症。与该病原体相关的颅内出血的报道甚至比脑积水更少,大多数病例发生在儿科人群中。在本文中,我们报告一例71岁男性患者发生该病原体菌血症,并伴有颅内出血。他最初表现为全身无力和疲劳的非特异性症状,后来出现嗜睡、定向障碍和发热,这促使进一步检查,结果显示存在颅内出血和该病原体菌血症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7e/9428365/813f85c7fcb6/cureus-0014-00000027562-i01.jpg

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