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霉酚酸酯治疗的老年患者中,颅内出血与单核细胞增生李斯特菌菌血症相关。

Intracranial Hemorrhage Associated With Listeria monocytogenes Bacteremia in an Elderly Patient on Mycophenolate Mofetil.

作者信息

Alammora Abdelkarim, Elamin Ahmed

机构信息

Internal Medicine Department, Hamad Medical Corporation, Doha, QAT.

出版信息

Cureus. 2022 Aug 1;14(8):e27562. doi: 10.7759/cureus.27562. eCollection 2022 Aug.

DOI:10.7759/cureus.27562
PMID:36059338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9428365/
Abstract

is an important foodborne bacterial pathogen in immunosuppressed patients, pregnant women, and individuals at the extremes of age, including neonates and older adults. Invasion of the central nervous system (CNS) and bacteremia are the principal clinical manifestations of infection in these hosts. In contrast, normal hosts who ingest high numbers of  may develop self-limited febrile gastroenteritis. Hydrocephalus and intracranial hemorrhage (ICH) are very rare and severe complications of infection. ICH associated with  has been reported even less frequently than hydrocephalus, with most cases occurring in the pediatric population. In this paper, we present a case of bacteremia in a 71-year-old male, complicated by intracranial hemorrhage. He presented at first with nonspecific symptoms of generalized weakness and fatigability and later developed drowsiness, disorientation, and fever, which prompted further investigations that revealed the presence of ICH and  bacteremia.

摘要

是免疫抑制患者、孕妇以及极端年龄人群(包括新生儿和老年人)中一种重要的食源性病原体。侵入中枢神经系统(CNS)和菌血症是这些宿主感染的主要临床表现。相比之下,摄入大量该病原体的正常宿主可能会发生自限性发热性胃肠炎。脑积水和颅内出血(ICH)是该病原体感染非常罕见且严重的并发症。与该病原体相关的颅内出血的报道甚至比脑积水更少,大多数病例发生在儿科人群中。在本文中,我们报告一例71岁男性患者发生该病原体菌血症,并伴有颅内出血。他最初表现为全身无力和疲劳的非特异性症状,后来出现嗜睡、定向障碍和发热,这促使进一步检查,结果显示存在颅内出血和该病原体菌血症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7e/9428365/813f85c7fcb6/cureus-0014-00000027562-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7e/9428365/813f85c7fcb6/cureus-0014-00000027562-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7e/9428365/813f85c7fcb6/cureus-0014-00000027562-i01.jpg

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本文引用的文献

1
Rhombencephalitis caused by with hydrocephalus and intracranial hemorrhage: A case report and review of the literature.由[病因未提及]引起的伴有脑积水和颅内出血的菱脑炎:一例报告及文献复习
World J Clin Cases. 2019 Feb 26;7(4):538-547. doi: 10.12998/wjcc.v7.i4.538.
2
Rhombencephalitis by Listeria Monocytogens in Two Diabetic Patients.两例糖尿病患者的单核细胞增生李斯特菌所致的菱形脑炎
Arch Iran Med. 2015 Sep;18(9):613-5.
3
Listeria brain abscesses during administration of mycophenolate mofetil for systemic lupus erythematosus: a case report.
霉酚酸酯治疗系统性红斑狼疮期间发生的李斯特菌脑脓肿:一例报告
Neurol Sci. 2015 Jun;36(6):1019-20. doi: 10.1007/s10072-014-1969-0. Epub 2014 Oct 1.
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Reservoirs of listeria species in three environmental ecosystems.三种环境生态系统中李斯特菌属的储存库。
Appl Environ Microbiol. 2014 Sep;80(18):5583-92. doi: 10.1128/AEM.01018-14. Epub 2014 Jul 7.
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What is new in listeriosis?李斯特菌病有哪些新情况?
Biomed Res Int. 2014;2014:358051. doi: 10.1155/2014/358051. Epub 2014 Apr 14.
6
Causes, consequences, and reversal of immune system aging.免疫系统衰老的原因、后果与逆转。
J Clin Invest. 2013 Mar;123(3):958-65. doi: 10.1172/JCI64096. Epub 2013 Mar 1.
7
Intracerebral hemorrhages in adults with community associated bacterial meningitis in adults: should we reconsider anticoagulant therapy?成人社区相关性细菌性脑膜炎并发脑内出血:我们是否应重新考虑抗凝治疗?
PLoS One. 2012;7(9):e45271. doi: 10.1371/journal.pone.0045271. Epub 2012 Sep 13.
8
Listeria monocytogenes serotypes in human infections (Italy, 2000-2010).人感染李斯特菌血清型(意大利,2000-2010 年)。
Ann Ist Super Sanita. 2012;48(2):146-50. doi: 10.4415/ANN_12_02_07.
9
Listeriosis: a resurgent foodborne infection.李斯特菌病:卷土重来的食源性感染。
Clin Microbiol Infect. 2010 Jan;16(1):16-23. doi: 10.1111/j.1469-0691.2009.03109.x.
10
Listerial rhombencephalitis in an immunocompetent young adult.免疫功能正常的年轻成年人中的李斯特菌性菱形脑炎。
Int J Infect Dis. 2009 Mar;13(2):e65-7. doi: 10.1016/j.ijid.2008.06.026. Epub 2008 Oct 16.