免疫系统衰老的原因、后果与逆转。
Causes, consequences, and reversal of immune system aging.
机构信息
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
出版信息
J Clin Invest. 2013 Mar;123(3):958-65. doi: 10.1172/JCI64096. Epub 2013 Mar 1.
Abstract
The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues. As a result, elderly individuals do not respond to immune challenge as robustly as the young. An important goal of aging research is to define the cellular changes that occur in the immune system and the molecular events that underlie them. Considerable progress has been made in this regard, and this information has provided the rationale for clinical trials to rejuvenate the aging immune system.
摘要
衰老对免疫系统的影响表现在多个层面，包括骨髓和胸腺中 B 细胞和 T 细胞生成减少，以及次级淋巴组织中成熟淋巴细胞功能下降。因此，老年人对免疫挑战的反应不如年轻人强烈。衰老研究的一个重要目标是定义免疫系统中发生的细胞变化以及它们的潜在分子事件。在这方面已经取得了相当大的进展，这些信息为使衰老的免疫系统年轻化的临床试验提供了依据。
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