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针对神经疾病的潜在疗法:基于天然产物的药物。

Potential therapeutics against neurological disorders: Natural products-based drugs.

作者信息

Rauf Abdur, Rahman Md Mominur

机构信息

Department of Chemistry, University of Swabi, Swabi, KPK, Pakistan.

Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh.

出版信息

Front Pharmacol. 2022 Aug 19;13:950457. doi: 10.3389/fphar.2022.950457. eCollection 2022.

Abstract

Neurodegenerative disorders, which are defined by the breakdown of neurons over time, are affecting an increasing number of people. Stroke, Alzheimer's, Parkinson's, Multiple Sclerosis, Migraine, and Amyotrophic Lateral Sclerosis are just a few examples of brain disorders that have no cure. Besides, there is a huge demand for drugs that can cure the diseases mentioned above because the majority of the medications we use to treat them only alleviate diseases. Different neurological disorders have responded satisfactorily to the pharmacological effects of medicinal plants. Despite the numerous multiple types of plants in the world, only a small number of them have been investigated for neurological disorders. As a result, there are many opportunities in this area for further research on plants and their bioactive chemicals. The search for natural therapeutic alternatives that promote faster healing and adverse effects avoidance has gained popularity in recent years. The aim of this mini-review is to explore some natural products that have strong therapeutic effects on neurodegenerative disorders such as Stroke, Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Migraine, Amyotrophic Lateral Sclerosis, and others. We have also shown the safety of natural products to improve their appropriate usage in neurological disorders from recent literature.

摘要

神经退行性疾病是由神经元随时间推移而退化所定义的,正影响着越来越多的人。中风、阿尔茨海默病、帕金森病、多发性硬化症、偏头痛和肌萎缩侧索硬化症只是一些无法治愈的脑部疾病的例子。此外,对于能够治愈上述疾病的药物有巨大需求,因为我们用于治疗这些疾病的大多数药物只能缓解病情。不同的神经疾病对药用植物的药理作用反应良好。尽管世界上有众多类型的植物,但只有少数植物针对神经疾病进行过研究。因此,在这一领域对植物及其生物活性化学物质进行进一步研究有很多机会。近年来,寻找能促进更快康复并避免不良反应的天然治疗替代品变得越来越流行。本综述的目的是探索一些对中风、阿尔茨海默病、帕金森病、多发性硬化症、偏头痛、肌萎缩侧索硬化症等神经退行性疾病有强大治疗作用的天然产物。我们还从近期文献中展示了天然产物的安全性,以促进其在神经疾病中的合理使用。

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