帕地霉素（U-70138F）对从癌症患者中分离出的革兰氏阳性菌的体外活性。
In vitro activity of paldimycin (U-70138F) against gram-positive bacteria isolated from patients with cancer.
作者信息
Rolston K V, LeBlanc B, Ho D H, Bodey G P
出版信息
Antimicrob Agents Chemother. 1987 Apr;31(4):650-2. doi: 10.1128/AAC.31.4.650.
Abstract
The in vitro activity of paldimycin, a novel antimicrobial agent, was compared with that of vancomycin against 306 gram-positive isolates (representing 12 bacterial species) obtained from patients with cancer. Paldimycin had lower MICs for 90% of isolates than vancomycin did against most isolates tested. Its activity, however, was medium and pH dependent, being greatest in Nutrient broth at a pH of 6.8.
摘要
将新型抗菌剂帕地霉素的体外活性与万古霉素针对从癌症患者中分离出的306株革兰氏阳性菌（代表12种细菌）的活性进行了比较。在大多数测试菌株中，帕地霉素对90%的菌株的最低抑菌浓度低于万古霉素。然而，其活性依赖于培养基和pH值，在pH为6.8的营养肉汤中活性最强。
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