Stamm W E, Suchland R
Antimicrob Agents Chemother. 1986 Nov;30(5):806-7. doi: 10.1128/AAC.30.5.806.
The MICs of three new antimicrobial agents of different classes, U-70138F, roxithromycin (RU 965), and ofloxacin (ORF 18489), versus Chlamydia trachomatis in McCoy cell cultures were 0.25, 0.8, and 1.0 microgram/ml, respectively. For each test drug, the MIC and MBC were identical or were within 1 dilution of one another. These drugs possessed sufficient activity in cell culture to suggest possible clinical effectiveness.
三种不同类型的新型抗菌剂U-70138F、罗红霉素(RU 965)和氧氟沙星(ORF 18489)在 McCoy 细胞培养物中对沙眼衣原体的最低抑菌浓度(MIC)分别为0.25、0.8和1.0微克/毫升。对于每种受试药物,MIC和最低杀菌浓度(MBC)相同或相差不超过1个稀释度。这些药物在细胞培养物中具有足够的活性,提示可能具有临床疗效。