U-70138F（帕地霉素）、罗红霉素（RU 965）和氧氟沙星（ORF 18489）在细胞培养中对沙眼衣原体的抗菌活性。
Antimicrobial activity of U-70138F (paldimycin), roxithromycin (RU 965), and ofloxacin (ORF 18489) against Chlamydia trachomatis in cell culture.
作者信息
Stamm W E, Suchland R
出版信息
Antimicrob Agents Chemother. 1986 Nov;30(5):806-7. doi: 10.1128/AAC.30.5.806.
Abstract
The MICs of three new antimicrobial agents of different classes, U-70138F, roxithromycin (RU 965), and ofloxacin (ORF 18489), versus Chlamydia trachomatis in McCoy cell cultures were 0.25, 0.8, and 1.0 microgram/ml, respectively. For each test drug, the MIC and MBC were identical or were within 1 dilution of one another. These drugs possessed sufficient activity in cell culture to suggest possible clinical effectiveness.
摘要
三种不同类型的新型抗菌剂U-70138F、罗红霉素（RU 965）和氧氟沙星（ORF 18489）在 McCoy 细胞培养物中对沙眼衣原体的最低抑菌浓度（MIC）分别为0.25、0.8和1.0微克/毫升。对于每种受试药物，MIC和最低杀菌浓度（MBC）相同或相差不超过1个稀释度。这些药物在细胞培养物中具有足够的活性，提示可能具有临床疗效。
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