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Comparison of the in vitro activities of ofloxacin and tetracycline against Chlamydia trachomatis as assessed by indirect immunofluorescence.通过间接免疫荧光法评估氧氟沙星和四环素对沙眼衣原体的体外活性比较。
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2
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3
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4
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5
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U-70138F（帕地霉素）、罗红霉素（RU 965）和氧氟沙星（ORF 18489）在细胞培养中对沙眼衣原体的抗菌活性。

Antimicrobial activity of U-70138F (paldimycin), roxithromycin (RU 965), and ofloxacin (ORF 18489) against Chlamydia trachomatis in cell culture.

作者信息

Stamm W E, Suchland R

出版信息

Antimicrob Agents Chemother. 1986 Nov;30(5):806-7. doi: 10.1128/AAC.30.5.806.

DOI:10.1128/AAC.30.5.806
PMID:3467650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176541/
Abstract

The MICs of three new antimicrobial agents of different classes, U-70138F, roxithromycin (RU 965), and ofloxacin (ORF 18489), versus Chlamydia trachomatis in McCoy cell cultures were 0.25, 0.8, and 1.0 microgram/ml, respectively. For each test drug, the MIC and MBC were identical or were within 1 dilution of one another. These drugs possessed sufficient activity in cell culture to suggest possible clinical effectiveness.

摘要

三种不同类型的新型抗菌剂U-70138F、罗红霉素（RU 965）和氧氟沙星（ORF 18489）在 McCoy 细胞培养物中对沙眼衣原体的最低抑菌浓度（MIC）分别为0.25、0.8和1.0微克/毫升。对于每种受试药物，MIC和最低杀菌浓度（MBC）相同或相差不超过1个稀释度。这些药物在细胞培养物中具有足够的活性，提示可能具有临床疗效。