Eron L J, Harvey L, Hixon D L, Poretz D M
Antimicrob Agents Chemother. 1985 Aug;28(2):308-10. doi: 10.1128/AAC.28.2.308.
Ciprofloxacin was administered orally to 48 patients with 24 Pseudomonas aeruginosa infections and 13 other infections caused by cephalothin-resistant gram-negative bacilli. The types of infections treated included those of skin or skin structure, bone, urinary tract, and respiratory tract. In 83% of P. aeruginosa infections, a favorable clinical outcome occurred, compared with 85% for all infections. Failure to achieve a cure correlated with the emergence of resistant P. aeruginosa and Acinetobacter calcoaceticus strains in four instances and superinfection with Candida (two cases) and Streptococcus (two cases) species. Therapy was discontinued in three patients because of the development of nausea. Ciprofloxacin appears to be safe and effective in the therapy of infections caused by resistant gram-negative bacilli.
对48例患者口服环丙沙星，其中24例感染铜绿假单胞菌，13例感染由耐头孢菌素革兰阴性杆菌引起的其他感染。治疗的感染类型包括皮肤或皮肤结构、骨骼、泌尿道和呼吸道感染。在83%的铜绿假单胞菌感染中，临床结果良好，所有感染的这一比例为85%。未治愈与4例出现耐药铜绿假单胞菌和醋酸钙不动杆菌菌株以及念珠菌（2例）和链球菌（2例）二重感染有关。3例患者因出现恶心而停药。环丙沙星在治疗由耐药革兰阴性杆菌引起的感染方面似乎是安全有效的。
