Alkahtani Abdullah M, Alraey Yasser, Zaman Gaffar Sarwar, Al-Shehri Hajri, Alghamdi Ibrahim Saeed, Chandramoorthy Harish C, Al-Hakami Ahmed M, Alamri Ahmad M, Alshehri Hassan Ali
Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
J Blood Med. 2022 Aug 27;13:447-459. doi: 10.2147/JBM.S365218. eCollection 2022.
The present investigation aims on the clinical attributes and haematological parameters between symptomatic (COVID-19 ICU) and asymptomatic (COVID-19 homes isolation) patients as predisposing sign for COVID-19 related mortality.
A retrospective cohort research was conducted of admitted patients to ICU, who were suffering from severe COVID-19 in Aseer Central Hospital, Abha, Kingdom of Saudi Arabia (KSA) from July 2020 until September 2020. The study included individuals with COVID -19 and ICU admission as symptomatic group and others who are COVID-19 positives with quarantine as asymptomatic group. Epidemiological, clinical and haematological laboratory data were retrospectively collected, analysed with control subjects.
Of the 38 ICU patients studied, the most common symptoms were fever and respiratory distress (100%), cough (86.8%). Majority were of Saudi origin (78.9%). Eighteen (47.4%) COVID-19 ICU patients showed leukocytosis, 6 (15.8%) had severe thrombocytopenia (with most having thrombocytopenia), 18 (47.4%) were anaemic. A significant correlation was observed between the WBC, RBC, Hb, platelets, neutrophil and lymphocyte count between ICU inmates compared with quarantine (p < 0.001) and RBC, Hb, neutrophil and lymphocyte count with control groups (p < 0.001).
From the observations it is evident that, the blood tests have potential clinical value in predicting COVID-19 progression. Further, patient characteristics including age, leukocyte count, RBC, platelets and differential leukocyte counts may be significant predictors for monitoring the progression of the critical illness observed in SARS-COV-2 patients. Also, treatment procedures can be re-defined further to reduce COVID-19 mortalities in more critically ill COVID-19 individuals.
本研究旨在探讨有症状（COVID-19重症监护病房）和无症状（COVID-19居家隔离）患者之间的临床特征和血液学参数，作为COVID-19相关死亡率的易感指标。
对2020年7月至2020年9月在沙特阿拉伯王国阿卜哈市阿西尔中心医院因严重COVID-19入住重症监护病房的患者进行回顾性队列研究。该研究将COVID-19且入住重症监护病房的患者作为有症状组，将其他COVID-19阳性且接受隔离的患者作为无症状组。回顾性收集流行病学、临床和血液学实验室数据，并与对照组进行分析。
在研究的38例重症监护病房患者中，最常见的症状是发热和呼吸窘迫（100%）、咳嗽（86.8%）。大多数患者为沙特人（78.9%）。18例（47.4%）COVID-19重症监护病房患者出现白细胞增多，6例（15.8%）有严重血小板减少（大多数有血小板减少），18例（47.4%）贫血。与隔离患者相比，重症监护病房患者的白细胞、红细胞、血红蛋白、血小板、中性粒细胞和淋巴细胞计数之间存在显著相关性（p<0.001），与对照组的红细胞、血红蛋白、中性粒细胞和淋巴细胞计数也存在显著相关性（p<0.001）。
从观察结果可以明显看出，血液检查在预测COVID-19进展方面具有潜在的临床价值。此外，包括年龄、白细胞计数、红细胞、血小板和白细胞分类计数在内的患者特征可能是监测SARS-CoV-2患者重症病情进展的重要预测指标。此外，可以进一步重新定义治疗程序，以降低病情更严重的COVID-19患者的死亡率。
