Marengo J T, Harrow M
Arch Gen Psychiatry. 1987 Jul;44(7):651-9. doi: 10.1001/archpsyc.1987.01800190071011.
This follow-up investigation examined the course of thought disorder in early, young schizophrenic, other psychotic, and nonpsychotic patients. Patients were assessed for the severity of thought disorder at index hospitalization and at two and four years after hospital discharge. Follow-up evaluations included assessments of adjustment and short-term outcome. Schizophrenic patients showed more thought disorder than nonschizophrenic patients at all three periods. Almost 40% (16/41) of the schizophrenic patients exhibited persistent thought disorder symptoms after the acute phase and an additional 37% (15/41) showed an episodic thought disorder course. Across diagnoses, patients who were thought disordered at both follow-ups demonstrated higher rates of unemployment and rehospitalization than did patients in non-thought-disordered and episodic thought disorder groups. To date, 25% (16/65) of psychotic nonschizophrenic patients showed persistent thought disorder courses similar to schizophrenia, while another 40% (24/65) showed remitting thought disorder symptoms more common to nonpsychotic patients.
这项随访调查研究了早期、青年精神分裂症患者、其他精神病患者以及非精神病患者的思维障碍病程。在首次住院时以及出院后两年和四年，对患者的思维障碍严重程度进行评估。随访评估包括对适应情况和短期结局的评估。在所有三个时间段，精神分裂症患者的思维障碍都比非精神分裂症患者更严重。近40%（16/41）的精神分裂症患者在急性期后表现出持续性思维障碍症状，另外37%（15/41）表现出发作性思维障碍病程。在所有诊断类型中，两次随访时均存在思维障碍的患者比非思维障碍组和发作性思维障碍组的患者失业率和再住院率更高。迄今为止，25%（16/65）的非精神分裂症精神病患者表现出与精神分裂症相似的持续性思维障碍病程，而另外40%（24/65）表现出非精神病患者更常见的思维障碍症状缓解情况。
