Musa Ayesha, Khan Safia, Mujahid Minahil, El-Gaby Mohamady
Green Templeton College, University of Oxford, Oxford, OX2 6HG, UK.
St Anne's college, University of Oxford, Oxford, OX2 6HS, UK.
Schizophrenia (Heidelb). 2022 Apr 7;8(1):34. doi: 10.1038/s41537-022-00247-7.
Memories are not formed in isolation. They are associated and organized into relational knowledge structures that allow coherent thought. Failure to express such coherent thought is a key hallmark of Schizophrenia. Here we explore the hypothesis that thought disorder arises from disorganized Hippocampal cognitive maps. In doing so, we combine insights from two key lines of investigation, one concerning the neural signatures of cognitive mapping, and another that seeks to understand lower-level cellular mechanisms of cognition within a dynamical systems framework. Specifically, we propose that multiple distinct pathological pathways converge on the shallowing of Hippocampal attractors, giving rise to disorganized Hippocampal cognitive maps and driving conceptual disorganization. We discuss the available evidence at the computational, behavioural, network, and cellular levels. We also outline testable predictions from this framework, including how it could unify major chemical and psychological theories of schizophrenia and how it can provide a rationale for understanding the aetiology and treatment of the disease.
记忆并非孤立形成。它们相互关联并组织成关系性知识结构，从而实现连贯思维。无法表达这种连贯思维是精神分裂症的一个关键特征。在此，我们探讨思维障碍源于海马体认知图谱紊乱这一假说。为此，我们结合了两条关键研究路线的见解，一条涉及认知图谱的神经特征，另一条则试图在动态系统框架内理解认知的低级细胞机制。具体而言，我们提出多种不同的病理途径汇聚于海马体吸引子的变浅，导致海马体认知图谱紊乱并引发概念混乱。我们讨论了在计算、行为、网络和细胞层面的现有证据。我们还概述了该框架的可测试预测，包括它如何能统一精神分裂症的主要化学和心理学理论，以及它如何能为理解该疾病的病因和治疗提供理论依据。
