Department of Geriatrics, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China.
Department of Emergency Medicine, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Front Endocrinol (Lausanne). 2024 Aug 16;15:1414402. doi: 10.3389/fendo.2024.1414402. eCollection 2024.
Given the limited evidence on the relationship between the triglyceride-glucose (TyG) index and the risk of prediabetes among young adults, our study aimed to investigate the potential impact of the TyG index on the future development of prediabetes in young individuals.
This retrospective cohort study included 125,327 healthy adults aged 20 to 45 years. We utilized Cox proportional hazards regression models, combined with cubic spline functions and smooth curve fitting, to assess the relationship between baseline TyG index and the risk of prediabetes among young adults, exploring its non-linear association. A series of sensitivity analyses and subgroup analyses were conducted to ensure the robustness of our findings.
After adjusting for covariates, the study found a positive correlation between the TyG index and the risk of prediabetes (HR=1.81, 95%CI: 1.54-2.13, p<0.0001). The risk of prediabetes increased progressively across quartiles of the TyG index (Q1 to Q4), with Q4 showing a significantly higher risk compared to Q1 (adjusted HR=2.33, 95% CI=1.72-3.16). Moreover, a non-linear relationship was identified between the TyG index and the risk of prediabetes, with an inflection point at 9.39. To the left of the inflection point, the HR was 2.04 (95% CI: 1.69 to 2.46), while to the right, the HR was 0.89 (95% CI: 0.48 to 1.65).
Our study reveals a non-linear relationship and a saturation effect between the TyG index and the development of prediabetes among young individuals in China, with an inflection point at 9.39. Understanding this non-linear relationship can assist clinicians in identifying young individuals at high risk and implementing targeted interventions to reduce their risk of progressing to diabetes.
鉴于甘油三酯-葡萄糖（TyG）指数与年轻人糖尿病前期风险之间关系的证据有限，本研究旨在探讨 TyG 指数对年轻人未来发生糖尿病前期的潜在影响。
本回顾性队列研究纳入了 125327 名年龄在 20 至 45 岁的健康成年人。我们利用 Cox 比例风险回归模型，结合三次样条函数和平滑曲线拟合，评估基线 TyG 指数与年轻人糖尿病前期风险之间的关系，探讨其非线性关联。进行了一系列敏感性分析和亚组分析，以确保研究结果的稳健性。
在校正了混杂因素后，研究发现 TyG 指数与糖尿病前期风险呈正相关（HR=1.81，95%CI：1.54-2.13，p<0.0001）。TyG 指数四分位区间（Q1 到 Q4）与糖尿病前期风险呈递增关系，Q4 与 Q1 相比风险显著增加（调整后的 HR=2.33，95%CI=1.72-3.16）。此外，TyG 指数与糖尿病前期风险之间存在非线性关系，拐点为 9.39。在拐点左侧，HR 为 2.04（95%CI：1.69-2.46），而在右侧，HR 为 0.89（95%CI：0.48-1.65）。
本研究揭示了 TyG 指数与中国年轻人糖尿病前期发展之间存在非线性关系和饱和效应，拐点为 9.39。了解这种非线性关系可以帮助临床医生识别处于高风险的年轻个体，并实施有针对性的干预措施，降低他们进展为糖尿病的风险。
