Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
West China School of Nursing, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2023 Dec 13;14:1295641. doi: 10.3389/fendo.2023.1295641. eCollection 2023.
The Triglyceride-glucose (TyG) index has been acknowledged as a convenient, cost-effective, and relatively simple marker for insulin resistance (IR). Meanwhile, prediabetes, described as an asymptomatic, moderately hyperglycemic state, tends to be more prevalent than diabetes. Thus, the objective of this study was to explore the relationship between the TyG index and the prevalence of both prediabetes and diabetes within the U.S. population.
This study utilized a cross-sectional dataset derived from the National Health and Nutrition Survey (NHANES) spanning 1999 to 2018. The subjects were individuals aged 18 years and above, who had available fasting glucose and fasting triglyceride information, permitting a diagnosis of prediabetes or diabetes. The TyG index was computed using laboratory data, and participants were subsequently categorized into quartiles based on this information. The relationship between the TyG index and the prevalence of prediabetes and diabetes was investigated using logistic regression analysis.
Out of the 25,159 participants, 23.88% were found to have prediabetes, while 16.22% were diagnosed with diabetes. After adjusting for confounding factors, a linear increase in relative odds was observed in Q2 (OR: 1.69; 95% CI: 1.52, 1.89), Q3 (OR: 2.57; 95% CI: 2.30, 2.88), and Q4 (OR: 4.88; 95% CI: 4.33, 5.49) groups in comparison to the reference group, Q1. In addition, a non-linear relationship was observed between the TyG index and the prevalence of prediabetes and diabetes. Specifically, patients with a TyG index greater than 8.00 overall exhibited a significantly higher risk of prediabetes and diabetes, confirming that an increase in the TyG index is associated with a corresponding increase in risk. However, this shift showed gender-specific variations; the threshold was observed at 8.00 in males but shifted to 9.00 in females.
The TyG index demonstrated a non-linear positive correlation with both prediabetes and diabetes. This suggests that maintaining the TyG index at a certain, reduced level could potentially aid in preventing the onset of prediabetes and diabetes.
三酰甘油-葡萄糖（TyG）指数已被公认为一种方便、经济且相对简单的胰岛素抵抗（IR）标志物。同时，前驱糖尿病被描述为一种无症状、中度高血糖状态，其发病率高于糖尿病。因此，本研究旨在探讨美国人群中 TyG 指数与前驱糖尿病和糖尿病患病率之间的关系。
本研究使用了 1999 年至 2018 年国家健康和营养调查（NHANES）的横断面数据集。研究对象为年龄在 18 岁及以上、有空腹血糖和空腹甘油三酯信息、可诊断为前驱糖尿病或糖尿病的个体。使用实验室数据计算 TyG 指数，并根据该信息将参与者分为四组。使用逻辑回归分析探讨 TyG 指数与前驱糖尿病和糖尿病患病率之间的关系。
在 25159 名参与者中，23.88%被诊断为前驱糖尿病，16.22%被诊断为糖尿病。调整混杂因素后，第 2 组（OR：1.69；95%CI：1.52，1.89）、第 3 组（OR：2.57；95%CI：2.30，2.88）和第 4 组（OR：4.88；95%CI：4.33，5.49）的相对优势比呈线性增加，与参考组第 1 组相比。此外，TyG 指数与前驱糖尿病和糖尿病的患病率之间存在非线性关系。具体来说，总体 TyG 指数大于 8.00 的患者前驱糖尿病和糖尿病的风险显著增加，证实 TyG 指数的增加与风险的相应增加有关。然而，这种变化存在性别特异性差异；男性的阈值为 8.00，而女性的阈值为 9.00。
TyG 指数与前驱糖尿病和糖尿病呈非线性正相关。这表明将 TyG 指数维持在一定的较低水平可能有助于预防前驱糖尿病和糖尿病的发生。
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