流感患者中循环 CD8+T 淋巴细胞激活与疾病严重程度的关系及其与疾病严重程度的关系。
Cycling and activated CD8 T lymphocytes and their association with disease severity in influenza patients.
机构信息
Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Shandong Key Laboratory of Infectious Respiratory Disease, Jinan, Shandong, China.
出版信息
BMC Immunol. 2022 Sep 5;23(1):40. doi: 10.1186/s12865-022-00516-1.
BACKGROUND
T cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T cells. It is necessary to clarify the T cells characteristics of kinetic changes and their correlation with disease severity.
METHODS
In a cohort of hospitalized influenza patients with varying degrees of severity, we characterized lymphocyte populations using flow cytometry.
RESULTS
The numbers of cycling (Ki67) T cells at the acute phase of severe influenza were higher, especially in the memory (CD45RO) T cell subsets. T cells from hospitalized influenza patients also had significantly higher levels of the exhausted marker PD-1. Cycling status of T cells was associated with T cell activation during the acute phase of influenza infection. The recruitment of cycling and activated (CD38HLA-DR) CD8 T cells subset is delayed in severe influenza patients.
CONCLUSIONS
The increased numbers of cycling memory (Ki67CD45RO) T cells subsets and delayed kinetics of activated (CD38HLA-DR) CD8 T cells, could serve as possible biological markers for disease severity.
背景
T 细胞淋巴细胞减少是严重流感感染的一个显著特征，与 T 细胞的功能变化有关。有必要阐明 T 细胞动力学变化的特征及其与疾病严重程度的相关性。
方法
在一组不同严重程度的住院流感患者中，我们使用流式细胞术对淋巴细胞群进行了特征描述。
结果
严重流感急性期循环（Ki67）T 细胞数量较高，尤其是在记忆（CD45RO）T 细胞亚群中。住院流感患者的 T 细胞也具有明显更高水平的耗竭标志物 PD-1。T 细胞的循环状态与流感感染急性期 T 细胞的激活有关。在严重流感患者中，循环和激活（CD38HLA-DR）CD8 T 细胞亚群的募集被延迟。
结论
循环记忆（Ki67CD45RO）T 细胞亚群数量增加和激活（CD38HLA-DR）CD8 T 细胞动力学延迟，可作为疾病严重程度的可能生物学标志物。
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