Bai Yixuan, Lei Chenggang, Zhang Na, Liu Yuhui, Hu Zhengyu, Li Yan, Qi Ran
Department of Digestive Internal Medicine, Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian, People's Republic of China.
Department of Hepatobiliary Surgery, Qingdao Municipal Hospital, Qingdao, People's Republic of China.
J Inflamm Res. 2022 Aug 30;15:4951-4961. doi: 10.2147/JIR.S378263. eCollection 2022.
The aim of this study was to identify clinical endoscopic indicators related to peri-ulcerative mucosal inflammation and to analyze whether the degree of peri-ulcerative mucosal inflammation appearance is an independent risk factor for gastric ulcer rebleeding.
We conducted a retrospective study that included patients with gastric ulcer bleeding who were hospitalized at three medical centers in China from January 1, 2016 to December 31, 2019. Ulcer rebleeding that occurred within 30 days of successful initial hemostasis was analyzed to determine whether this event was related to the degree of peri-ulcerative mucosal inflammation appearance or other mucosal inflammation-related factors.
We enrolled 1111 patients and determined that GBS-Rebleeding-ROC (P<0.001), age (P=0.01), use of NSAIDs (P=0.001), bile reflux (P<0.001), and (P<0.001) are all risk factors for peri-ulcerative mucosal inflammation appearance. Through multivariate analysis, we determined that severe peri-ulcerative mucosal inflammation appearance (P=0.002) was an independent risk factor for ulcer rebleeding within 30 days. Finally, we developed a risk assessment model using factors associated with mucosal inflammation that may be useful for early prediction of rebleeding.
The risk factors for peri-ulcerative mucosal inflammation appearance were identified. Severe peri-ulcerative mucosal inflammation appearance is an independent risk factor for ulcer rebleeding.
本研究旨在确定与溃疡周围黏膜炎症相关的临床内镜指标，并分析溃疡周围黏膜炎症表现程度是否为胃溃疡再出血的独立危险因素。
我们进行了一项回顾性研究，纳入了2016年1月1日至2019年12月31日在中国三个医疗中心住院的胃溃疡出血患者。分析首次止血成功后30天内发生的溃疡再出血情况，以确定该事件是否与溃疡周围黏膜炎症表现程度或其他与黏膜炎症相关的因素有关。
我们纳入了1111例患者，确定GBS - 再出血 - ROC（P<0.001）、年龄（P = 0.01）、非甾体抗炎药的使用（P = 0.001）、胆汁反流（P<0.001）以及（此处原文缺失内容）（P<0.001）均为溃疡周围黏膜炎症表现的危险因素。通过多因素分析，我们确定严重的溃疡周围黏膜炎症表现（P = 0.002）是30天内溃疡再出血的独立危险因素。最后，我们利用与黏膜炎症相关的因素建立了一个风险评估模型，该模型可能有助于早期预测再出血。
确定了溃疡周围黏膜炎症表现的危险因素。严重的溃疡周围黏膜炎症表现是溃疡再出血的独立危险因素。
