Ali Abd El-Rahman Heba, Omar Amel Ramadan
Faculty of Science, Department of Zoology, Cairo University, Giza, Egypt.
Andrologia. 2022 Dec;54(11):e14580. doi: 10.1111/and.14580. Epub 2022 Sep 6.
Lufenuron is a benzoylurea pesticide that causes significant histological and histochemical damage in mammals. Avocado is a common food in the human diet that contains antioxidant and antitumor properties. In male rats, avocado oil's protection against lufenuron-induced reproductive deterioration, oxidative stress, and DNA damages was investigated. Twenty-eight mature male rats were selected and distributed into four groups: Group 1, control group were administered distilled water orally; Group 2 received 4 ml/kg avocado; Group 3 was given lufenuron (1.6 mg/kg), and Group 4 was given avocado oil/lufenuron. The findings show that lufenuron treatment reduces reproductive hormone levels, sperm count, motility, viability and causes negative histopathological changes in testicular tissue, such as decreased epithelial height and increased luminal diameter degenerated spermatogenesis. Furthermore, lufenuron reduced the content of antioxidant enzymes while increasing the level of malondialdehyde, nitric oxide and corresponding DNA damage. Results showed that lufenuron is associated with testicular function impairment, which leads to infertility. Treatment with avocado oil improved reproductive hormone secretions, enzymatic activity, histological and DNA damage parameters in testis tissues, reducing the negative effects of lufenuron, proving that it may have a therapeutic role against lufenuron-mediated testicular toxicity.
虱螨脲是一种苯甲酰脲类杀虫剂，可对哺乳动物造成显著的组织学和组织化学损伤。鳄梨是人类饮食中的常见食物，具有抗氧化和抗肿瘤特性。在雄性大鼠中，研究了鳄梨油对虱螨脲诱导的生殖功能衰退、氧化应激和DNA损伤的保护作用。选取28只成熟雄性大鼠，分为四组：第1组为对照组，口服蒸馏水；第2组给予4毫升/千克鳄梨；第3组给予虱螨脲（1.6毫克/千克），第4组给予鳄梨油/虱螨脲。研究结果表明，虱螨脲处理会降低生殖激素水平、精子数量、活力和存活率，并在睾丸组织中引起负面的组织病理学变化，如上皮高度降低、管腔直径增加以及生精过程退化。此外，虱螨脲会降低抗氧化酶的含量，同时增加丙二醛、一氧化氮的水平以及相应的DNA损伤。结果表明，虱螨脲与睾丸功能损害有关，可导致不育。鳄梨油处理可改善睾丸组织中的生殖激素分泌、酶活性、组织学和DNA损伤参数，减轻虱螨脲的负面影响，证明其可能对虱螨脲介导的睾丸毒性具有治疗作用。
