Birch K, Jørgensen J, Chraemmer-Jørgensen B, Kehlet H
Br J Anaesth. 1987 Jun;59(6):721-4. doi: 10.1093/bja/59.6.721.
Pain intensity, and blood glucose and plasma cortisol concentrations were measured following abdominal hysterectomy in 18 patients allocated randomly to receive either i.v. lignocaine 1.5 mg kg-1 plus 2 mg kg-1 h-1, or saline. The administration of lignocaine resulted in plasma concentrations between 1.5 and 2.0 micrograms ml-1 during the 2-h study period. However, the administration of lignocaine i.v. had no effect on the intensity of pain after surgery, or on the adrenocortical and hyperglycaemic responses to surgery.
对18例随机分配接受静脉注射1.5mg/kg利多卡因加2mg/kg·h⁻¹或生理盐水的患者，在腹部子宫切除术后测量疼痛强度、血糖和血浆皮质醇浓度。在2小时的研究期间，利多卡因给药导致血浆浓度在1.5至2.0微克/毫升之间。然而，静脉注射利多卡因对术后疼痛强度或对手术的肾上腺皮质和高血糖反应没有影响。
