Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Department of Pathology, UPMC, Pittsburgh, Pennsylvania, USA.
Diagn Cytopathol. 2022 Nov;50(11):532-537. doi: 10.1002/dc.25053. Epub 2022 Sep 7.
Malignant pleural mesothelioma (MPM) is a rare but aggressive malignancy with a poor prognosis. Because of this tumor rarity and overlapping histologic features with other malignancy types, the histopathological findings and diagnostic immunohistochemical workup are essential in establishing the final diagnosis of MPMs. We aimed to review the diagnostic criteria, WHO tumor classification updates, and immunohistochemical staining markers diagnostic value to achieve an appropriate clinical diagnosis.
恶性胸膜间皮瘤（MPM）是一种罕见但具有侵袭性的恶性肿瘤，预后不良。由于这种肿瘤的罕见性和与其他恶性肿瘤类型的重叠组织学特征，组织病理学发现和诊断免疫组织化学检查在确定 MPM 的最终诊断中至关重要。我们旨在回顾诊断标准、世界卫生组织肿瘤分类更新以及免疫组织化学染色标记物的诊断价值，以实现适当的临床诊断。
