Department of Basic Science, University of Transport and Communications, Hanoi 11512, Vietnam.
Department of Structural Research, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi 10072, Vietnam.
J Asian Nat Prod Res. 2023 Jun;25(6):603-609. doi: 10.1080/10286020.2022.2113975. Epub 2022 Sep 7.
One new phenylpropanoid glycoside, tinosinen A () and 13 known compounds, tinosinen (), citrusin B (), picraquassioside C (), -guaiacylglycerol---4'-coniferyl alcohol (), -guaiacylglycerol-8--4'-(sinapyl alcohol) ether (), -syringylglycerol-8--4'-(sinapyl alcohol) ether (), -isolariciresinol 9--D--glucopyranoside (), tinosposide A (), pinoresinol-4'--D-glucopyranoside (), syringaresinol-4'---D-glucopyranoside (), pinoresinol (), syringaresinol (), and lirioresino--dimethyl ether () were isolated from the stems of (Lour.) Merr. Their structures were established by detailed spectroscopic studies and comparisons with those reported in the literature. Compound showed significant inhibitory NO production (IC value of 38.53 ± 1.90 μM) in RAW264.7 macrophages, LPS-stimulated. Compounds -, , , and inhibited NO production with IC values ranging from 38.53 to 99.07 μM.
从（Lour.）Merr 的茎中分离得到了一种新的苯丙素糖苷，即 tinosinen A () 和 13 种已知化合物，包括 tinosinen (), citrusin B (), picraquassioside C (), -guaiacylglycerol---4'-coniferyl alcohol (), -guaiacylglycerol-8--4'-(sinapyl alcohol) ether (), -syringylglycerol-8--4'-(sinapyl alcohol) ether (), -isolariciresinol 9--D--glucopyranoside (), tinosposide A (), pinoresinol-4'--D-glucopyranoside (), syringaresinol-4'---D-glucopyranoside (), pinoresinol (), syringaresinol (), 和 lirioresino--dimethyl ether ()。通过详细的光谱研究和与文献报道的化合物进行比较，确定了它们的结构。化合物 显示出对 RAW264.7 巨噬细胞中 LPS 刺激产生的 NO 有显著的抑制作用（IC 值为 38.53±1.90μM）。化合物 -,,, 和 对 NO 产生的抑制作用，IC 值范围为 38.53 至 99.07μM。
