Liu Xin-Lian, Zhang You-Ya, Li Lin, Tan Lu-Qi, Huang Yin-Ai, Ma Ai-Jun, Peng Jin-Bao
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, PR China.
Org Lett. 2022 Sep 16;24(36):6692-6696. doi: 10.1021/acs.orglett.2c02839. Epub 2022 Sep 7.
A palladium-catalyzed ligand-controlled selective 1,4-addition and cycloaddition reaction of β,γ-unsaturated α-ketoesters with alkylidenecyclopropanes (ACPs) has been developed. Using ACPs and β,γ-unsaturated α-ketoesters as starting materials, γ-dienyl-α-ketoesters and dihydro-2-pyrans could be prepared selectively by modulating the ligand. A range of multisubstituted α-ketoesters and dihydro-2-pyrans were obtained in moderate to excellent yields with excellent regioselectivities.
已开发出一种钯催化的、配体控制的β,γ-不饱和α-酮酯与亚烷基环丙烷（ACPs）的选择性1,4-加成和环加成反应。以ACPs和β,γ-不饱和α-酮酯为原料，通过调节配体可选择性地制备γ-二烯基-α-酮酯和二氢-2-吡喃。一系列多取代的α-酮酯和二氢-2-吡喃以中等至优异的产率和优异的区域选择性获得。
