Department of Endocrinology, Key Laboratory of Endocrinology, National Commission of Health, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Shanxi Dayi Hospital, Taiyuan, Shanxi, China.
Arch Osteoporos. 2022 Sep 7;17(1):120. doi: 10.1007/s11657-022-01158-x.
In this population-based, cross-sectional study, we investigated vertebral fracture (VF) prevalence among Chinese postmenopausal women. We found 14.7% of population had VFs, which increased with age. Age ≥ 65 years, hip fracture, and densitometric osteoporosis were significantly associated with VFs. The prevalence of osteoporosis was remarkably high.
To investigate VF prevalence among Chinese postmenopausal women in this population-based, randomized-sampling, cross-sectional study.
The investigator obtained lists of women from communities. Randomization was performed using SAS programming based on age group in each region. Postmenopausal women aged ≥ 50 years in the urban community were included. The investigator interviewed subjects to collect self-reported data and measured BMD. Spine radiographs were adjudicated by Genant's semi-quantitative method. VFs were defined as fractures of at least one vertebra classified by Genant's score 1-3 and were analyzed using descriptive statistics.
A total of 31,205 women listed for randomized sampling from 10 Tier-3 hospitals at 5 regions. Of 2634 women in the full analysis set, 14.7% (388/2634, 95% CI: 13.4, 17.1) had prevalent VFs. VF prevalence increased with age (Cochran-Armitage test p < 0.0001) and was significantly higher in women aged ≥ 65. VF prevalence did not differ between North (14.4%, 95% CI: 12.5, 16.4) and South China (15.1%, 95% CI: 13.3, 17.1). In women with no prior VFs, prevalent VFs were 12.4% (95% CI: 11.2, 13.7). Age ≥ 65 years (OR: 2.57, 95% CI: 1.91, 3.48), hip fracture (OR: 2.28, 95% CI: 1.09, 4.76), and densitometric osteoporosis (OR: 2.52, 95% CI: 1.96, 3.22) were significantly associated with prevalent VFs. Prevalence of osteoporosis was 32.9% measured by BMD and 40.8% using NOF/IOF clinical diagnosis criteria.
VFs are prevalent among Chinese postmenopausal women who were ≥ 50 years and community-dwelled. Osteoporosis prevalence is remarkable when fragile fractures were part of clinical diagnosis.
在这项基于人群的、随机抽样的横断面研究中，调查中国绝经后妇女的椎体骨折（VF）患病率。
研究者从社区获得女性名单。使用基于每个地区年龄组的 SAS 编程进行随机分组。纳入年龄≥50 岁的城市社区绝经后妇女。研究者通过询问调查对象收集自报告数据并测量 BMD。通过 Genant 的半定量方法对脊柱 X 线片进行裁决。VF 定义为至少有一个椎体骨折，根据 Genant 评分 1-3 进行分类，并使用描述性统计进行分析。
共从 5 个地区的 10 家 3 级医院列出了 31205 名接受随机抽样的女性。在全分析集的 2634 名女性中，14.7%（388/2634，95%CI：13.4，17.1）有现患 VF。VF 患病率随年龄增加（Cochran-Armitage 检验，p<0.0001），且在≥65 岁的女性中显著更高。在无既往 VF 的女性中，现患 VF 患病率为 12.4%（95%CI：11.2，13.7）。年龄≥65 岁（OR：2.57，95%CI：1.91，3.48）、髋部骨折（OR：2.28，95%CI：1.09，4.76）和骨质疏松症（OR：2.52，95%CI：1.96，3.22）与现患 VF 显著相关。使用 BMD 测量的骨质疏松症患病率为 32.9%，使用 NOF/IOF 临床诊断标准的骨质疏松症患病率为 40.8%。
在中国≥50 岁和居住在社区的绝经后妇女中，VF 较为常见。当脆性骨折纳入临床诊断时，骨质疏松症的患病率则相当高。
