在人类受精过程中，MAIA（Fc受体样蛋白3）取代JUNO成为IZUMO1的受体。
MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization.
作者信息
Vondrakova Jana, Frolikova Michaela, Ded Lukas, Cerny Jiri, Postlerova Pavla, Palenikova Veronika, Simonik Ondrej, Nahacka Zuzana, Basus Krystof, Valaskova Eliska, Machan Radek, Pacey Allan, Holubcova Zuzana, Koubek Pavel, Ezrova Zuzana, Park Soojin, Liu Ruiwu, Partha Raghavendran, Clark Nathan, Neuzil Jiri, Ikawa Masahito, Erickson Kent, Lam Kit S, Moore Harry, Komrskova Katerina
机构信息
Laboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Laboratory of Structural Bioinformatics of Proteins, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
出版信息
Sci Adv. 2022 Sep 9;8(36):eabn0047. doi: 10.1126/sciadv.abn0047. Epub 2022 Sep 7.
Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.
配子融合是哺乳动物受精过程中的关键事件。一个随机的单珠单化合物组合肽库代表了合成的人类卵子模拟物，并鉴定出一种以前未被识别的配体为Fc受体样3，以与朱诺交织在一起的神话女神命名为MAIA。这种免疫球蛋白超家族受体在人类身上表达，并在精卵黏附和融合过程中发挥主要作用。MAIA与已知的IZUMO1/朱诺精卵复合体形成高度稳定的相互作用，从而实现特异性配子融合。MAIA同种型的复杂性可能提供一种隐秘的性选择机制，以避免基因不相容并实现良好的适应性结果。
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