Willbrand Ethan H, Parker Benjamin J, Voorhies Willa I, Miller Jacob A, Lyu Ilwoo, Hallock Tyler, Aponik-Gremillion Lyndsey, Koslov Seth R, Bunge Silvia A, Foster Brett L, Weiner Kevin S
Department of Psychology, University of California, Berkeley, Berkeley, CA 94720 USA.
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720 USA.
Sci Adv. 2022 Sep 9;8(36):eabn9516. doi: 10.1126/sciadv.abn9516. Epub 2022 Sep 7.
Understanding brain structure-function relationships, and their development and evolution, is central to neuroscience research. Here, we show that morphological differences in posterior cingulate cortex (PCC), a hub of functional brain networks, predict individual differences in macroanatomical, microstructural, and functional features of PCC. Manually labeling 4511 sulci in 572 hemispheres, we found a shallow cortical indentation (termed the inframarginal sulcus; ) within PCC that is absent from neuroanatomical atlases yet colocalized with a focal, functional region of the lateral frontoparietal network implicated in cognitive control. This structural-functional coupling generalized to meta-analyses consisting of hundreds of studies and thousands of participants. Additional morphological analyses showed that unique properties of the differ across the life span and between hominoid species. These findings support a classic theory that shallow, tertiary sulci serve as landmarks in association cortices. They also beg the question: How many other cortical indentations have we missed?
理解脑结构与功能的关系及其发展和演化是神经科学研究的核心。在此，我们表明，作为功能性脑网络枢纽的后扣带回皮质（PCC）的形态差异可预测PCC在大体解剖、微观结构和功能特征方面的个体差异。我们手动标记了572个半球中的4511条脑沟，发现在PCC内有一个浅的皮质凹陷（称为缘下沟），神经解剖图谱中没有该结构，但它与外侧额顶网络中一个与认知控制有关的局灶性功能区域共定位。这种结构-功能耦合在由数百项研究和数千名参与者组成的荟萃分析中也得到了验证。进一步的形态学分析表明，缘下沟的独特属性在整个生命周期以及类人猿物种之间存在差异。这些发现支持了一个经典理论，即浅的三级脑沟是联合皮质中的地标。它们也引出了一个问题：我们还遗漏了多少其他的皮质凹陷？
