Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.
Sci Data. 2022 Sep 7;9(1):549. doi: 10.1038/s41597-022-01637-3.
An inappropriate diet is a risk factor for inflammatory bowel disease (IBD). It is established that the consumption of spicy food containing capsaicin is strongly associated with the recurrence and worsening of IBD symptoms. Moreover, capsaicin can induce neutrophil accumulation in the lamina propria, contributing to disease deterioration. To uncover the potential signaling pathway involved in capsaicin-induced relapse and the effects of capsaicin on neutrophil activation, we performed proteomic analyses of intestinal tissues from chronic colitis mice following capsaicin administration and transcriptomic analyses of dHL-60 cells after capsaicin stimulation. Collectively, these multiomic analyses identified proteins and genes that may be involved in disease flares, thereby providing new insights for future research.
饮食不当是炎症性肠病（IBD）的一个风险因素。已经确定，食用含有辣椒素的辛辣食物与 IBD 症状的复发和恶化密切相关。此外，辣椒素可诱导固有层中性粒细胞聚集，导致疾病恶化。为了揭示辣椒素诱导复发的潜在信号通路以及辣椒素对中性粒细胞激活的影响，我们对给予辣椒素后的慢性结肠炎小鼠的肠道组织进行了蛋白质组学分析，并对辣椒素刺激后的 dHL-60 细胞进行了转录组学分析。总的来说，这些多组学分析确定了可能与疾病发作有关的蛋白质和基因，为未来的研究提供了新的见解。
