Peng Zifang, Zhang Wenfen, Zhang Xu, Mao Jian, Zhang Qidong, Zhao Wuduo, Zhang Shusheng, Xie Jianping
College of Chemistry, Zhengzhou University, Zhengzhou, Henan, China.
Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, China.
Front Nutr. 2023 Jul 28;10:1227517. doi: 10.3389/fnut.2023.1227517. eCollection 2023.
Capsaicin is the main food active component in that has gained considerable attention due to its broad biological activities, including antioxidation, anti-inflammation, anti-tumor, weight regulation, cardiac protection, anti-calculi, and diurnal-circadian regulation. The potent biological effects of capsaicin are intimately related to metabolic pathways such as lipid metabolism, energy metabolism, and antioxidant stress. Mass spectrometry (MS) has emerged as an effective tool for deciphering the mechanisms underlying capsaicin metabolism and its biological impacts. However, it remains challenging to accurately identify and quantify capsaicin and its self-metabolites in complex food and biological samples, and to integrate multi-omics data generated from MS. In this work, we summarized recent advances in the detection of capsaicin and its self-metabolites using MS and discussed the relevant MS-based studies of metabolic pathways. Furthermore, we discussed current issues and future directions in this field. In-depth studies of capsaicin metabolism and its physiological functions based on MS is anticipated to yield new insights and methods for preventing and treating a wide range of diseases.
辣椒素是[具体内容缺失]中的主要食物活性成分，因其具有广泛的生物活性而备受关注，这些活性包括抗氧化、抗炎、抗肿瘤、体重调节、心脏保护、抗结石和昼夜节律调节。辣椒素强大的生物学效应与脂质代谢、能量代谢和抗氧化应激等代谢途径密切相关。质谱（MS）已成为一种有效的工具，用于解读辣椒素代谢及其生物学影响的潜在机制。然而，在复杂的食物和生物样品中准确鉴定和定量辣椒素及其自身代谢产物，以及整合从质谱生成的多组学数据，仍然具有挑战性。在这项工作中，我们总结了使用质谱检测辣椒素及其自身代谢产物的最新进展，并讨论了基于质谱的代谢途径相关研究。此外，我们还讨论了该领域当前存在的问题和未来的发展方向。基于质谱对辣椒素代谢及其生理功能进行深入研究，有望为预防和治疗多种疾病带来新的见解和方法。
